23S rRNA 突变使铜绿假单胞菌对阿奇霉素产生耐药性。
Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa.
机构信息
Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark.
出版信息
Antimicrob Agents Chemother. 2012 Aug;56(8):4519-21. doi: 10.1128/AAC.00630-12. Epub 2012 May 29.
Abstract
The emergence of antibiotic-resistant Pseudomonas aeruginosa is an important concern in the treatment of long-term airway infections in cystic fibrosis patients. In this study, we report the occurrence of azithromycin resistance among clinical P. aeruginosa DK2 isolates. We demonstrate that resistance is associated with specific mutations (A2058G, A2059G, and C2611T in Escherichia coli numbering) in domain V of 23S rRNA and that introduction of A2058G and C2611T into strain PAO1 results in azithromycin resistance.
摘要
铜绿假单胞菌对抗生素的耐药性的出现是囊性纤维化患者长期气道感染治疗中的一个重要关注点。在这项研究中，我们报告了临床分离的铜绿假单胞菌 DK2 株对阿奇霉素耐药的发生。我们证明耐药性与 23S rRNA 结构域 V 中的特定突变（大肠杆菌编号为 A2058G、A2059G 和 C2611T）相关，并且将 A2058G 和 C2611T 引入菌株 PAO1 中可导致阿奇霉素耐药。
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