• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

高剂量达托霉素联合磷霉素治疗耐甲氧西林敏感和耐甲氧西林金黄色葡萄球菌心内膜炎安全有效。

High-dose daptomycin plus fosfomycin is safe and effective in treating methicillin-susceptible and methicillin-resistant Staphylococcus aureus endocarditis.

机构信息

Hospital Clínic-IDIBAPS, University of Barcelona, Barcelona, Spain.

出版信息

Antimicrob Agents Chemother. 2012 Aug;56(8):4511-5. doi: 10.1128/AAC.06449-11. Epub 2012 May 29.

DOI:10.1128/AAC.06449-11
PMID:22644033
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3421550/
Abstract

We describe 3 patients with left-sided staphylococcal endocarditis (1 with methicillin-susceptible Staphylococcus aureus [MSSA] prosthetic aortic valve endocarditis and 2 with methicillin-resistant S. aureus [MRSA] native-valve endocarditis) who were successfully treated with high-dose intravenous daptomycin (10 mg/kg/day) plus fosfomycin (2 g every 6 h) for 6 weeks. This combination was tested in vitro against 7 MSSA, 5 MRSA, and 2 intermediately glycopeptide-resistant S. aureus isolates and proved to be synergistic against 11 (79%) strains and bactericidal against 8 (57%) strains. This combination deserves further clinical study.

摘要

我们描述了 3 例左侧葡萄球菌性心内膜炎患者（1 例为耐甲氧西林金黄色葡萄球菌 [MSSA] 人工主动脉瓣心内膜炎，2 例为耐甲氧西林金黄色葡萄球菌 [MRSA] 原生瓣膜心内膜炎），他们均成功接受了 6 周高剂量静脉滴注达托霉素（10mg/kg/天）加磷霉素（每 6 小时 2g）治疗。该联合用药在体外对 7 株 MSSA、5 株 MRSA 和 2 株中度糖肽耐药金黄色葡萄球菌分离株进行了测试，结果显示对 11 株（79%）菌株具有协同作用，对 8 株（57%）菌株具有杀菌作用。这种联合用药值得进一步的临床研究。

相似文献

1
High-dose daptomycin plus fosfomycin is safe and effective in treating methicillin-susceptible and methicillin-resistant Staphylococcus aureus endocarditis.高剂量达托霉素联合磷霉素治疗耐甲氧西林敏感和耐甲氧西林金黄色葡萄球菌心内膜炎安全有效。
Antimicrob Agents Chemother. 2012 Aug;56(8):4511-5. doi: 10.1128/AAC.06449-11. Epub 2012 May 29.
2
Emerging issues on endocarditis and the role in therapy of daptomycin plus fosfomycin.关于心内膜炎的新问题和磷霉素联合达托霉素在治疗中的作用。
Expert Rev Anti Infect Ther. 2023 Mar;21(3):281-293. doi: 10.1080/14787210.2023.2174969. Epub 2023 Feb 10.
3
The Combination of Daptomycin and Fosfomycin Has Synergistic, Potent, and Rapid Bactericidal Activity against Methicillin-Resistant Staphylococcus aureus in a Rabbit Model of Experimental Endocarditis.达托霉素与磷霉素联合应用对实验性兔心内膜炎耐甲氧西林金黄色葡萄球菌具有协同、强效、快速杀菌作用。
Antimicrob Agents Chemother. 2018 May 25;62(6). doi: 10.1128/AAC.02633-17. Print 2018 Jun.
4
Successful treatment with daptomycin and ceftaroline of MDR Staphylococcus aureus native valve endocarditis: a case report.成功使用达托霉素和头孢洛林治疗耐多药金黄色葡萄球菌自体瓣膜心内膜炎：一例报告。
J Antimicrob Chemother. 2019 Sep 1;74(9):2626-2630. doi: 10.1093/jac/dkz253.
5
Telavancin in therapy of experimental aortic valve endocarditis in rabbits due to daptomycin-nonsusceptible methicillin-resistant Staphylococcus aureus.替拉万星治疗兔实验性主动脉瓣心内膜炎的疗效，该模型由耐甲氧西林金黄色葡萄球菌（daptomycin 不敏感株）引起。
Antimicrob Agents Chemother. 2012 Nov;56(11):5528-33. doi: 10.1128/AAC.00922-12. Epub 2012 Aug 13.
6
Efficacy and safety of fosfomycin plus imipenem as rescue therapy for complicated bacteremia and endocarditis due to methicillin-resistant Staphylococcus aureus: a multicenter clinical trial.磷霉素联合亚胺培南治疗耐甲氧西林金黄色葡萄球菌引起的复杂性菌血症和心内膜炎的疗效和安全性：一项多中心临床试验。
Clin Infect Dis. 2014 Oct 15;59(8):1105-12. doi: 10.1093/cid/ciu580. Epub 2014 Jul 21.
7
Comparison of ceftaroline fosamil, daptomycin and tigecycline in an experimental rabbit endocarditis model caused by methicillin-susceptible, methicillin-resistant and glycopeptide-intermediate Staphylococcus aureus.比较头孢洛林磷酸酯、达托霉素和替加环素在耐甲氧西林金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌和糖肽中介金黄色葡萄球菌引起的实验性兔心内膜炎模型中的作用。
J Antimicrob Chemother. 2011 Apr;66(4):863-6. doi: 10.1093/jac/dkr019. Epub 2011 Jan 31.
8
Daptomycin is effective in treatment of experimental endocarditis due to methicillin-resistant and glycopeptide-intermediate Staphylococcus aureus.达托霉素对耐甲氧西林和糖肽类中介金黄色葡萄球菌引起的实验性心内膜炎治疗有效。
Antimicrob Agents Chemother. 2008 Jul;52(7):2538-43. doi: 10.1128/AAC.00510-07. Epub 2008 Apr 21.
9
Daptomycin versus vancomycin plus gentamicin for treatment of bacteraemia and endocarditis due to Staphylococcus aureus: subset analysis of patients infected with methicillin-resistant isolates.达托霉素与万古霉素加庆大霉素治疗耐甲氧西林金黄色葡萄球菌所致菌血症和心内膜炎：耐甲氧西林分离株感染患者的亚组分析
J Antimicrob Chemother. 2008 Dec;62(6):1413-21. doi: 10.1093/jac/dkn372. Epub 2008 Sep 8.
10
Fosfomycin plus β-Lactams as Synergistic Bactericidal Combinations for Experimental Endocarditis Due to Methicillin-Resistant and Glycopeptide-Intermediate Staphylococcus aureus.磷霉素联合β-内酰胺类药物作为耐甲氧西林和糖肽类中介金黄色葡萄球菌所致实验性心内膜炎的协同杀菌组合
Antimicrob Agents Chemother. 2015 Nov 2;60(1):478-86. doi: 10.1128/AAC.02139-15. Print 2016 Jan.

引用本文的文献

1
Antibiofilm efficacy of emodin alone or combined with ampicillin against methicillin-resistant Staphylococcus aureus.大黄素单独或与氨苄西林联合应用对耐甲氧西林金黄色葡萄球菌的抗生物膜作用
Sci Rep. 2025 Jul 1;15(1):21904. doi: 10.1038/s41598-025-06800-5.
2
Use of Daptomycin to Manage Severe MRSA Infections in Humans.使用达托霉素治疗人类严重耐甲氧西林金黄色葡萄球菌感染。
Antibiotics (Basel). 2025 Jun 18;14(6):617. doi: 10.3390/antibiotics14060617.
3
Antibiotic synergy against : a systematic review and meta-analysis.抗生素协同作用：一项系统评价与荟萃分析
Antimicrob Agents Chemother. 2025 Aug 6;69(8):e0119924. doi: 10.1128/aac.01199-24. Epub 2025 Jun 17.
4
PBP4 is required for serum-induced cell wall thickening and antibiotic tolerance in .PBP4 对于血清诱导的细胞壁增厚和抗生素耐受是必需的。
Antimicrob Agents Chemother. 2024 Nov 6;68(11):e0096124. doi: 10.1128/aac.00961-24. Epub 2024 Oct 21.
5
Antibiotic Resistance to Molecules Commonly Prescribed for the Treatment of Antibiotic-Resistant Gram-Positive Pathogens: What Is Relevant for the Clinician?对常用于治疗耐抗生素革兰氏阳性病原体的分子的抗生素耐药性：临床医生应关注什么？
Pathogens. 2024 Jan 19;13(1):88. doi: 10.3390/pathogens13010088.
6
New Antimicrobials and New Therapy Strategies for Endocarditis: Weapons That Should Be Defended.感染性心内膜炎的新型抗菌药物及新治疗策略：需加以捍卫的武器
J Clin Med. 2023 Dec 14;12(24):7693. doi: 10.3390/jcm12247693.
7
Antimicrobial Resistance: Two-Component Regulatory Systems and Multidrug Efflux Pumps.抗菌耐药性：双组分调节系统与多药外排泵
Antibiotics (Basel). 2023 May 26;12(6):965. doi: 10.3390/antibiotics12060965.
8
Fosfomycin for Non-Urinary Tract Infections: a systematic review.磷霉素用于非尿路感染：一项系统评价
Infez Med. 2023 Jun 1;31(2):163-173. doi: 10.53854/liim-3102-4. eCollection 2023.
9
Targeted Therapy of Severe Infections Caused by in Critically Ill Adult Patients: A Multidisciplinary Proposal of Therapeutic Algorithms Based on Real-World Evidence.危重症成年患者由[具体病原体未给出]引起的严重感染的靶向治疗：基于真实世界证据的治疗算法多学科建议。
Microorganisms. 2023 Feb 3;11(2):394. doi: 10.3390/microorganisms11020394.
10
Silver Nanoparticles and Its Mechanistic Insight for Chronic Wound Healing: Review on Recent Progress.银纳米颗粒及其在慢性伤口愈合中的作用机制：最新进展综述。
Molecules. 2022 Aug 30;27(17):5587. doi: 10.3390/molecules27175587.

本文引用的文献

1
Use of antistaphylococcal beta-lactams to increase daptomycin activity in eradicating persistent bacteremia due to methicillin-resistant Staphylococcus aureus: role of enhanced daptomycin binding.利用抗葡萄球菌β-内酰胺类药物提高达托霉素对耐甲氧西林金黄色葡萄球菌持续性菌血症的清除作用：增强达托霉素结合的作用。
Clin Infect Dis. 2011 Jul 15;53(2):158-63. doi: 10.1093/cid/cir340.
2
High-dose daptomycin and fosfomycin treatment of a patient with endocarditis caused by daptomycin-nonsusceptible Staphylococcus aureus: case report.高剂量达托霉素和磷霉素治疗达托霉素不敏感金黄色葡萄球菌引起的心内膜炎患者：病例报告。
BMC Infect Dis. 2011 May 26;11:152. doi: 10.1186/1471-2334-11-152.
3
Induction kinetics of the Staphylococcus aureus cell wall stress stimulon in response to different cell wall active antibiotics.金黄色葡萄球菌细胞壁应激应答基因簇在不同细胞壁活性抗生素作用下的诱导动力学研究
BMC Microbiol. 2011 Jan 20;11:16. doi: 10.1186/1471-2180-11-16.
4
Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children.美国传染病学会发布的耐甲氧西林金黄色葡萄球菌感染成人和儿童治疗临床实践指南。
Clin Infect Dis. 2011 Feb 1;52(3):e18-55. doi: 10.1093/cid/ciq146. Epub 2011 Jan 4.
5
Fosfomycin: an old, new friend?磷霉素：故友还是新朋？
Eur J Clin Microbiol Infect Dis. 2010 Feb;29(2):127-42. doi: 10.1007/s10096-009-0833-2. Epub 2009 Nov 14.
6
Clinical significance of the pharmacokinetic and pharmacodynamic characteristics of fosfomycin for the treatment of patients with systemic infections.磷霉素治疗全身感染患者的药代动力学和药效学特征的临床意义。
Int J Antimicrob Agents. 2009 Dec;34(6):506-15. doi: 10.1016/j.ijantimicag.2009.08.013. Epub 2009 Oct 13.
7
Addition of gentamicin or rifampin does not enhance the effectiveness of daptomycin in treatment of experimental endocarditis due to methicillin-resistant Staphylococcus aureus.添加庆大霉素或利福平并不能增强达托霉素治疗耐甲氧西林金黄色葡萄球菌所致实验性心内膜炎的有效性。
Antimicrob Agents Chemother. 2009 Oct;53(10):4172-7. doi: 10.1128/AAC.00051-09. Epub 2009 Jul 20.
8
Fosfomycin for the treatment of infections caused by Gram-positive cocci with advanced antimicrobial drug resistance: a review of microbiological, animal and clinical studies.磷霉素治疗具有先进抗微生物药物耐药性的革兰阳性球菌引起的感染：微生物学、动物和临床研究综述。
Expert Opin Investig Drugs. 2009 Jul;18(7):921-44. doi: 10.1517/13543780902967624.
9
Transcriptional profiling reveals that daptomycin induces the Staphylococcus aureus cell wall stress stimulon and genes responsive to membrane depolarization.转录谱分析表明，达托霉素可诱导金黄色葡萄球菌细胞壁应激刺激因子及对膜去极化有反应的基因。
Antimicrob Agents Chemother. 2008 Mar;52(3):980-90. doi: 10.1128/AAC.01121-07. Epub 2007 Dec 17.
10
Daptomycin in the treatment of patients with infective endocarditis: experience from a registry.达托霉素治疗感染性心内膜炎患者：一项注册研究的经验
Am J Med. 2007 Oct;120(10 Suppl 1):S28-33. doi: 10.1016/j.amjmed.2007.07.011.