Franzini Angelo, Leone Massimo, Messina Giuseppe, Cordella Roberto, Marras Carlo, Bussone Gennaro, Broggi Giovanni
Neurological Institute Foundation C. Besta, Milan, Italy.
Neurol Sci. 2008 May;29 Suppl 1:S65-8. doi: 10.1007/s10072-008-0891-8.
The field of neuromodulation is emerging as a promising and alternative therapeutical option for many drug-resistant clinical conditions, including painful syndromes such as refractory chronic cluster headache (CCH) and trigeminal neuralgia. We here report a series of patients who have undergone Deep Brain Stimulation (DBS) of Posterior Hypothalamus for chronic cluster headache, trigeminal neuralgia and atypical facial pain, matching their corresponding clinical results and also suggesting a role for Great Occipital Nerve Stimulation (which is a much less invasive procedure) in the treatment of CCH. According to us, the refinement of surgical techniques and of metabolic and functional brain neuroradiological investigations will lead to a refinement of the therapeutical strategies in such patients.
神经调节领域正在成为许多耐药性临床病症的一种有前景的替代治疗选择，包括难治性慢性丛集性头痛（CCH）和三叉神经痛等疼痛综合征。我们在此报告了一系列接受下丘脑后部深部脑刺激（DBS）治疗慢性丛集性头痛、三叉神经痛和非典型面部疼痛的患者，匹配了他们相应的临床结果，并提示枕大神经刺激（这是一种侵入性小得多的手术）在CCH治疗中的作用。据我们所知，手术技术以及代谢和功能性脑神经放射学检查的改进将导致此类患者治疗策略的改进。
