桥连偶氮苯衍生物对肽构象的双向光控。
Bidirectional photocontrol of peptide conformation with a bridged azobenzene derivative.
机构信息
Dept. of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada.
出版信息
Angew Chem Int Ed Engl. 2012 Jun 25;51(26):6452-5. doi: 10.1002/anie.201202383. Epub 2012 May 29.
PMID:22644657
Abstract
It goes both ways: A thiol-reactive cross-linker based on a bridged azobenzene derivative permits photoreversible control of peptide conformation on irradiation with violet (407 nm) and green (500-550 nm) light (see picture) through isomerization of the cross-linker. The large separation of the absorbance bands of the cis (yellow) and trans (red) isomers enables complete bidirectional photoswitching.
摘要
它是双向的
基于桥连偶氮苯衍生物的硫醇反应性交联剂允许通过光异构化来控制肽构象的光可逆性，其使用的光波长分别为紫色（407nm）和绿色（500-550nm）（见图）。顺式（黄色）和反式（红色）异构体的吸收带的大分离使得完全双向光开关成为可能。
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