Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.
Arch Pharm Res. 2012 May;35(5):779-84. doi: 10.1007/s12272-012-0503-2. Epub 2012 May 29.
Two new cadinane-type sesquiterpenoids, scabralins A (1) and B (2) were obtained from the soft coral Sinularia scabra. Metabolite 1 was shown to exhibit moderate to weak cytotoxicity against MCF-7, WiDr, Daoy, and HEp 2 cancer cell lines. Also, incubation with 10 µM compound 1 significantly inhibited the accumulation of the pro-inflammatory inducible nitric oxide synthase protein in lipopolysaccharide-stimulated RAW264.7 macrophage cells.
从软珊瑚 Sinularia scabra 中分离得到了两个新的卡丹烷型倍半萜类化合物，分别命名为 scabralin A（1）和 B（2）。化合物 1 对 MCF-7、WiDr、Daoy 和 HEp 2 癌细胞系表现出中等至较弱的细胞毒性。此外，在 10 μM 化合物 1 孵育下，显著抑制了脂多糖刺激的 RAW264.7 巨噬细胞中促炎诱导型一氧化氮合酶蛋白的积累。
