台湾软珊瑚 Lemnalia flava 的那沙定倍半萜。

Nardosinane sesquiterpenoids from the Formosan soft coral Lemnalia flava.

机构信息

Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan, Republic of China.

出版信息

J Nat Prod. 2011 Feb 25;74(2):169-74. doi: 10.1021/np100541a. Epub 2011 Jan 4.

DOI:10.1021/np100541a

PMID:21204521

Abstract

Four new nardosinane-type sesquiterpenoids, flavalins A-D (1-4), have been isolated from the Formosan soft coral Lemnalia flava. The structures of the new metabolites were determined by extensive spectroscopic analysis, and the structure of 2 was confirmed by X-ray diffraction analysis. A plausible biosynthetic pathway to 1 and 2 is proposed. Compound 1 was found to display dose-dependent inhibition of iNOS protein expression, and 1 and 2 were shown to possess significant neuroprotective activity.

摘要

从台湾软珊瑚 Lemnalia flava 中分离得到了 4 种新的纳多辛烷型倍半萜类化合物 flavalins A-D（1-4）。通过广泛的光谱分析确定了新代谢物的结构，通过 X 射线衍射分析确定了 2 的结构。提出了 1 和 2 的可能生物合成途径。发现化合物 1 对 iNOS 蛋白表达具有剂量依赖性抑制作用，并且 1 和 2 表现出显著的神经保护活性。