Winkler A M, Josephson C D
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Medical Director, Grady Health System Transfusion Service, Atlanta, GA 30322, USA.
Immunohematology. 2012;28(1):24-6.
The Atlanta Sickle Cell Consortium represents more than 2600 pediatric and adult patients with sickle cell disease (SCD) in the metropolitan Atlanta, Georgia, area receiving care at four major locations, each providing comprehensive care 24 hours a day, 7 days a week. Both transfusion services that support these sites use two levels of prospective phenotype matching to decrease the rates of alloimmunization. Although exact rates are unknown and are currently under investigation, alloimmunization occurs infrequently with the exception of chronically transfused SCD patients, who represent the minority of active SCD patients. With increasing availability, red blood cell genotyping will be used in the near future both for determination of predicted patient phenotypes and for provision of genotypically matched donor units.
亚特兰大镰状细胞病联盟代表了佐治亚州亚特兰大大都市地区2600多名患有镰状细胞病（SCD）的儿童和成人患者，他们在四个主要地点接受治疗，每个地点每周7天、每天24小时提供全面护理。支持这些地点的输血服务都采用了两级前瞻性表型匹配，以降低同种免疫的发生率。虽然确切发生率尚不清楚且目前正在调查中，但除了长期接受输血的SCD患者（他们占活跃SCD患者的少数）外，同种免疫很少发生。随着可用性的提高，红细胞基因分型在不久的将来将用于确定预测的患者表型以及提供基因匹配的供体单位。
