Biomedical Research Centre, Norwich School of Medicine, University of East Anglia, Norwich, NR4 7TJ, UK.
Cell Microbiol. 2012 Sep;14(9):1345-53. doi: 10.1111/j.1462-5822.2012.01818.x. Epub 2012 Jul 4.
It is widely accepted that Trypanosoma cruzi can exploit the natural exocytic response of the host to cell damage, utilizing host cell lysosomes as important effectors. It is, though, increasingly clear that the parasite also exploits endocytic mechanisms which allow for incorporation of plasma membrane into the parasitophorous vacuole. Further, that these endocytic mechanisms are involved in cross-talk with the exocytic machinery, in the recycling of vesicles and in the manipulation of the cytoskeleton. Here we review the mechanisms by which T. cruzi exploits features of the exocytic and endocytic pathways in epithelial and endothelial cells and the evidence for cross-talk between these pathways.
人们普遍认为，克氏锥虫可以利用宿主细胞对细胞损伤的自然胞吐反应，利用宿主细胞溶酶体作为重要的效应器。不过，越来越清楚的是，寄生虫还利用内吞作用机制，将质膜纳入滋养体空泡。此外，这些内吞作用机制参与与胞吐机制的交流、囊泡的再循环以及细胞骨架的操纵。在这里，我们回顾了克氏锥虫在肠上皮细胞和血管内皮细胞中利用胞吐和胞吞途径的特征的机制，以及这些途径之间相互作用的证据。
