Laudanski Piotr, Raba Grzegorz, Kuc Pawel, Lemancewicz Adam, Kisielewski Rafał, Laudanski Tadeusz
Department of Perinatology, Medical University of Białystok, Poland.
J Matern Fetal Neonatal Med. 2012 Dec;25(12):2696-9. doi: 10.3109/14767058.2012.699116.
The differential diagnosis between preterm and false labour remains one of the most challenging issues in perinatal medicine.
To assess the prognostic importance of the selected biochemical markers in predicting preterm labour.
74 patients hospitalized due to threatening preterm labour. 51 women gave birth prematurely; the remaining 23 were diagnosed with false labour. We used ELISA arrays to study 13 proteins: IGFBP-1, IGFBP-2, BDNF, L-Selectin, E-Selectin, ICAM-1, PECAM, VCAM-1, MIP-1 delta (MIP-1d) MIP-3β (MIP-3b), Eotaxin-1, Eotaxin-2, BLC.
An increased risk of preterm labour should be expected when the serum concentration for: IGFBP-1 > 158.83 pg/ml (sens. 0.608, sp. 0.609, p < 0.0001); MIP-1d < 27.66 pg/ml (sens. 0.627, sp. 0.627, p = 0.021); BDNF >36.54 pg/ml (sens. 0.630, sp. 0.647, p = 0.002); BLC >25.46 pg/ml (sens. 0.588, sp. 0.609, p < 0.001); Eotaxin-1 >1.16 pg/ml (sens. 0.633, sp. 0.652).
There have been reported statistically significant differences in serum concentrations of selected proteins in women with preterm labour and false labour.
早产与假临产的鉴别诊断仍然是围产期医学中最具挑战性的问题之一。
评估所选生化标志物在预测早产中的预后重要性。
74例因先兆早产住院的患者。51例妇女早产；其余23例被诊断为假临产。我们使用酶联免疫吸附测定阵列研究13种蛋白质：胰岛素样生长因子结合蛋白-1（IGFBP-1）、胰岛素样生长因子结合蛋白-2（IGFBP-2）、脑源性神经营养因子（BDNF）、L-选择素、E-选择素、细胞间黏附分子-1（ICAM-1）、血小板内皮细胞黏附分子（PECAM）、血管细胞黏附分子-1（VCAM-1）、巨噬细胞炎性蛋白-1δ（MIP-1δ，MIP-1d）、巨噬细胞炎性蛋白-3β（MIP-3β，MIP-3b）、嗜酸性粒细胞趋化因子-1、嗜酸性粒细胞趋化因子-2、B淋巴细胞趋化因子（BLC）。
当血清浓度满足以下条件时，早产风险增加：IGFBP-1>158.83 pg/ml（敏感性0.608，特异性0.609，p<0.0001）；MIP-1d<27.66 pg/ml（敏感性0.627，特异性0.627，p = 0.021）；BDNF>36.54 pg/ml（敏感性0.630，特异性0.647，p = 0.０02）；BLC>25.46 pg/ml（敏感性0.588，特异性0.609，p<0.001）；嗜酸性粒细胞趋化因子-1>1.16 pg/ml（敏感性0.633，特异性0.652）。
据报道，早产和假临产妇女血清中所选蛋白质的浓度存在统计学上的显著差异。
