Department of Gynecology, University Hospital Zurich, 8091 Zurich, Switzerland.
Laboratory for Translational Research in Medicine, Centre for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszów, 35-310 Rzeszów, Poland.
J Pregnancy. 2024 May 7;2024:6620156. doi: 10.1155/2024/6620156. eCollection 2024.
The cannabinoid receptor (CBR) plays a significant role in oogenesis, pregnancy, and childbirth. It might also play a significant role in preterm birth (PTB). The aim of the study was to investigate the association between the expression of the CBR in the placenta and the incidence of PTB. This prospective, observational, multicentre preliminary study was conducted on placental samples obtained from 109 women. The study included 95 patients hospitalized due to the high risk of PTB. They were divided into two groups: Group 1, where the expression of the CBR1 and CBR1a was analyzed, and Group 2, in which we examined CBR2 expression. The control group, that is, Group 3, consisted of 14 women who delivered at term, and their placentas were tested for the presence of all three receptor types (CBR1, CBR1a, and CBR2). The study used reverse transcription and real-time PCR methods to assess the expression of CBRs in the placental tissues. The expression of the CBR2, CBR1, and CBR1a receptors was significantly lower in the placentas of women after PTB compared to those after term births, = 0.038, 0.033, and 0.034, respectively. The presence of CBR mRNA in the human placental tissue was confirmed. The decreased expression of CBRs could serve as an indicator in predicting PTB.
大麻素受体 (CBR) 在卵母细胞发生、妊娠和分娩中起着重要作用。它在早产 (PTB) 中也可能起着重要作用。本研究旨在探讨胎盘 CBR 表达与 PTB 发生率之间的关系。
这项前瞻性、观察性、多中心初步研究对 109 名妇女的胎盘样本进行了研究。该研究纳入了因 PTB 高危而住院的 95 名患者。他们分为两组：第 1 组分析 CBR1 和 CBR1a 的表达，第 2 组检测 CBR2 的表达。对照组（第 3 组）包括 14 名足月分娩的妇女，对其胎盘进行了三种受体类型（CBR1、CBR1a 和 CBR2）的检测。
研究采用逆转录和实时 PCR 方法评估胎盘组织中 CBR 的表达。与足月分娩的妇女相比，PTB 后妇女的 CBR2、CBR1 和 CBR1a 受体的表达显著降低，分别为 = 0.038、0.033 和 0.034。
在人胎盘组织中证实了 CBR mRNA 的存在。CBR 表达的降低可作为预测 PTB 的指标。
