一种新的立体控制合成路线，从 D-葡萄糖经 Padwa 烯丙基砜[3+2]-阴离子环加成消除制备（-）-echinosporin。
A new stereocontrolled synthetic route to (-)-echinosporin from D-glucose via Padwa allenylsulfone [3 + 2]-anionic cycloadditive elimination.
机构信息
The School of Chemistry and Chemical Engineering, and the CCRCB, Queen's University Belfast, Stranmillis Road, Belfast BT9 5AG, Northern Ireland, UK.
出版信息
Org Lett. 2012 Jun 15;14(12):3024-7. doi: 10.1021/ol301090v. Epub 2012 May 30.
PMID:22646909
Abstract
A new formal total synthesis of (-)-echinosporin has been developed based upon the Padwa [3 + 2]-cycloadditive elimination reaction of allenylsulfone 4 with the D-glucose-derived enone 14 which provides cycloadduct 12.
摘要
基于 Padwa [3 + 2]-环加成消除反应，我们开发了一种新型的 (-)-echinosporin 的全合成方法，其中 allenylsulfone 4 与 D-葡萄糖衍生的烯酮 14 反应，生成环加成产物 12。
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