Pitkäranta P
Department of Diagnostic Radiology, University Central Hospital, Helsinki, Finland.
Ann Chir Gynaecol. 1990;79(3):129-33.
Chronic pancreatitis was induced in eight piglets by dividing all pancreatic attachments to the duodenum. Five piglets served as controls. The animals which were operated on were autopsied six weeks thereafter. Ductography and microangiography were performed. Histological preparations of pancreatic tissue were made. All of the animals which underwent operation developed histologically verified chronic pancreatitis. Ductography revealed the main ducts and the side branches to be considerably dilated. They also exhibited variations in calibre and sudden obstructions. Two animals had a large non-infected pseudocyst. No communication between the cyst and the main duct could be demonstrated by ductography. No pancreatic calcifications were seen. The vasculature of the ductal plexuses seems to be derived from interlobular arteries. The animals with chronic pancreatitis had marked diminution of the vascular supply of the ducts. The changes in ductal vascularity correlated with the severity of the histological changes to the pancreas and may, thus, in part explain the progress of pancreatitis.
通过分离胰腺与十二指肠的所有附着部位，在八头仔猪中诱发慢性胰腺炎。五头仔猪作为对照。手术动物在六周后进行尸检。进行了导管造影和微血管造影。制作了胰腺组织的组织学标本。所有接受手术的动物均出现了经组织学证实的慢性胰腺炎。导管造影显示主胰管和分支胰管明显扩张。它们还表现出管径变化和突然阻塞。两只动物有一个大的非感染性假性囊肿。导管造影未显示囊肿与主胰管之间有连通。未发现胰腺钙化。导管丛的血管似乎源自小叶间动脉。患有慢性胰腺炎的动物其导管的血管供应明显减少。导管血管的变化与胰腺组织学变化的严重程度相关，因此可能部分解释胰腺炎的进展。
