Pitkäranta P, Kivisaari L, Nordling S, Saari A, Schröder T
Dept. of Diagnostic Radiology, Helsinki University Central Hospital, Finland.
Scand J Gastroenterol. 1989 Oct;24(8):987-92. doi: 10.3109/00365528909089245.
Chronic pancreatitis was induced in 22 piglets by dividing all pancreatic attachments to the duodenum; five sham-operated piglets served as controls. Two piglets died of postoperative complications. The animals were autopsied 2, 4, or 6 weeks postoperatively. All operated animals developed chronic pancreatitis. Concomitant with the development of interstitial fibrosis, an increasing progressive atrophy of the exocrine parenchyma occurred, with preservation of the islets of Langerhans. This atrophy and fibrosis were considerable already after 2 weeks. In one piglet only there was some acute inflammation and fat necrosis, whereas all showed at least moderate chronic inflammation, which did not change with time. The growth of the piglets stopped, and all had diarrhoea, which was thought to reflect exocrine insufficiency. Two animals (9%) developed a large pancreatic pseudocyst, and all animals had wide pancreatic ducts. The endocrine function was undisturbed. Intravenous glucose tolerance tests showed that the animals did not become diabetic. This model is appropriate for the study of experimental pancreatitis.
通过分离胰腺与十二指肠的所有附着部位，在22只仔猪中诱发慢性胰腺炎；5只假手术仔猪作为对照。2只仔猪死于术后并发症。术后2、4或6周对动物进行尸检。所有手术动物均发生慢性胰腺炎。伴随着间质纤维化的发展，外分泌实质出现进行性萎缩，胰岛得以保留。2周后，这种萎缩和纤维化就很明显了。仅1只仔猪出现了一些急性炎症和脂肪坏死，而所有仔猪均表现出至少中度的慢性炎症，且炎症程度不随时间变化。仔猪生长停止，均出现腹泻，认为这反映了外分泌功能不全。2只动物（9%）出现了大的胰腺假性囊肿，所有动物的胰管均增宽。内分泌功能未受影响。静脉葡萄糖耐量试验表明这些动物未患糖尿病。该模型适用于实验性胰腺炎的研究。
