小GTP酶的一项重大新任务。
A big new job for small GTPases.
作者信息
Carmena Ana
机构信息
Instituto de Neurociencias, CSIC/UMH, 03550-Sant Joan d'Alacant, Alicante, Spain.
出版信息
Small GTPases. 2012 Jul-Sep;3(3):159-62. doi: 10.4161/sgtp.19631. Epub 2012 May 31.
Abstract
Members of the Ras superfamily of small guanosine triphosphatases (GTPases) function as key nodes within signaling networks in a remarkable range of cellular processes, including cell proliferation, differentiation, growth, cell-cell adhesion and apoptosis. We recently described a novel role for the Ras-like small GTPases Rap1 and Ral in regulating cortical polarity and spindle orientation during asymmetric neuroblast division in Drosophila. The participation of these proteins in promoting cell polarization seems to be a common theme throughout evolution.
摘要
小GTP酶（鸟苷三磷酸酶）的Ras超家族成员在一系列显著的细胞过程中作为信号网络中的关键节点发挥作用，这些过程包括细胞增殖、分化、生长、细胞间粘附和凋亡。我们最近描述了Ras样小GTP酶Rap1和Ral在果蝇不对称神经母细胞分裂过程中调节皮质极性和纺锤体方向方面的新作用。这些蛋白质在促进细胞极化中的参与似乎是整个进化过程中的一个共同主题。
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