The University of Queensland, NHMRC Centre of Clinical Research Excellence in Spinal Pain, Injury and Health, Australia.
Clin Neurophysiol. 2012 Sep;123(9):1698-704. doi: 10.1016/j.clinph.2012.05.003. Epub 2012 May 28.
In the last decade transcranial magnetic stimulation (TMS) has been the subject of more than 20,000 original research articles. Despite this popularity, TMS responses are known to be highly variable and this variability can impact on interpretation of research findings. There are no guidelines regarding the factors that should be reported and/or controlled in TMS studies. This study aimed to develop a checklist to be recommended to evaluate the methodology and reporting of studies that use single or paired pulse TMS to study the motor system. A two round international web-based Delphi study was conducted. Panellists rated the importance of a number of subject, methodological and analytical factors to be reported and/or controlled in studies that use single or paired pulse TMS to study the motor system. Twenty-seven items for single pulse studies and 30 items for paired pulse studies were included in the final checklist. Eight items related to subjects (e.g. age, gender), 21 to methodology (e.g. coil type, stimulus intensity) and two to analysis (e.g. size of the unconditioned motor evoked potential). The checklist is recommended for inclusion when submitting manuscripts for publication to ensure transparency of reporting and could also be used to critically appraise previously published work. It is envisaged that factors could be added and deleted from the checklist on the basis of future research. Use of the TMS methodological checklist should improve the quality of data collection and reporting in TMS studies of the motor system.
在过去的十年中，经颅磁刺激（TMS）已经成为超过 20,000 篇原始研究文章的主题。尽管如此，TMS 反应众所周知具有高度可变性，这种可变性会影响对研究结果的解释。目前还没有关于 TMS 研究中应报告和/或控制哪些因素的指南。本研究旨在制定一份检查表，以建议评估使用单次或双脉冲 TMS 研究运动系统的研究的方法和报告。进行了两轮国际基于网络的 Delphi 研究。小组成员对在使用单次或双脉冲 TMS 研究运动系统的研究中应报告和/或控制的一些受试者、方法学和分析因素的重要性进行了评分。最终检查表中包含了 27 项用于单脉冲研究的项目和 30 项用于双脉冲研究的项目。8 项与受试者相关（例如年龄、性别），21 项与方法学相关（例如线圈类型、刺激强度），2 项与分析相关（例如未受条件影响的运动诱发电位的大小）。建议在提交手稿供发表时使用该检查表，以确保报告的透明度，也可以用于批判性评估以前发表的工作。预计可以根据未来的研究从检查表中添加和删除因素。使用 TMS 方法学检查表应该会提高运动系统 TMS 研究中数据收集和报告的质量。
