Tsyganenko A Ia, Topuzov V S, Kalinichenko N F, Kovalenko N I, Davidenko V B, Gabysheva L S, Liapunov N A, Starobinets Z G, Osolodchenko T P, Vasil'chenko V N
Antibiot Khimioter. 1990 Aug;35(8):39-41.
Antibacterial properties of the Soviet drug nitazol which is a derivative of imidazole were studied. It was shown that nitazol in a dose of 4-8 micrograms/ml was highly active against gram-negative nonsporulating anaerobes, gram-positive anaerobic cocci and spore-forming Clostridia spp. Unlike metronidazole, it was efficient against both standard and clinical strains of facultative anaerobes such as E. coli, S. aureus and Klebsiella spp. isolated from patients with peritonitis and being poly-resistant to antibiotics. It was found in vitro that the antibacterial effect of nitazol was higher when it was used in combination with some antibiotics. It was demonstrated on experimental models of peritonitis caused by Staphylococcus spp. and E. coli in mice that nitazol used alone or in combination with gentamicin had a favourable effect on the animal survival and lifespan. The combination of nitazol with gentamicin was applied in the combined treatment of appendicular peritonitis in 80 children and its high therapeutic efficacy was stated. Nitazol is useful as an antibacterial drug in the combined treatment of children with purulent peritonitis.
对苏联药物硝唑（一种咪唑衍生物）的抗菌特性进行了研究。结果表明，剂量为4 - 8微克/毫升的硝唑对革兰氏阴性无芽孢厌氧菌、革兰氏阳性厌氧球菌和产芽孢梭菌属具有高度活性。与甲硝唑不同，它对兼性厌氧菌的标准菌株和临床菌株均有效，如从腹膜炎患者分离出的对多种抗生素耐药的大肠杆菌、金黄色葡萄球菌和克雷伯菌属。体外研究发现，硝唑与某些抗生素联合使用时，其抗菌效果更佳。在小鼠由金黄色葡萄球菌和大肠杆菌引起的腹膜炎实验模型中证明，单独使用硝唑或与庆大霉素联合使用对动物的存活率和寿命有良好影响。硝唑与庆大霉素的联合用药应用于80例儿童阑尾性腹膜炎的联合治疗，并证实了其高治疗效果。硝唑作为一种抗菌药物在儿童化脓性腹膜炎的联合治疗中很有用。
