[硫酸庆大霉素化疗活性的实验研究]
[Experimental study of the chemotherapeutic activity of gentamicin sulfate].
作者信息
Lobuseva A N, Petrova M A, Pozdniakova V P, Berezina E K, Fomina I P
出版信息
Antibiotiki. 1976 Sep;21(9):832-8.
Antibacterial activity of gentamycin sulfate was studied in vitro and in treatment of albino mice with experimental infections. Gentamycin was superior to kanamycin with respect to its antibacterial effect against clinical strains of Staphylococcus, Coli bacteria, Proteus and Ps. aeruginosa. High efficiency of gentamycin was found with respect to acute and chronic staphylococcal infection, acute Proteus and Coli sepsis. The antibiotic was characterized by low LD50, high chemotherapeutic index, rapid decrease in isolation of the causative agent from the animal organs. The activity of gentamycin against infections caused by Ps. aeruginosa was the main advantage of gentamycin in comparison to kanamycin.
对硫酸庆大霉素的抗菌活性进行了体外研究，并用于治疗患有实验性感染的白化小鼠。就其对葡萄球菌、大肠杆菌、变形杆菌和铜绿假单胞菌临床菌株的抗菌效果而言，庆大霉素优于卡那霉素。在急性和慢性葡萄球菌感染、急性变形杆菌和大肠杆菌败血症方面发现庆大霉素具有高效性。该抗生素的特点是半数致死量低、化疗指数高、从动物器官中分离出病原体的速度迅速下降。与卡那霉素相比，庆大霉素对铜绿假单胞菌引起的感染的活性是其主要优势。
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