尼日利亚东部槲寄生（Loranthus micranthus Linn.）提取物和馏分的抗蠕动作用。

Antimotility effects of extracts and fractions of Eastern Nigeria mistletoe (Loranthus micranthus Linn).

机构信息

Department of Pharmaceutical and Medicinal Chemistry, University of Nigeria, Nsukka, Enugu State, Nigeria.

出版信息

Asian Pac J Trop Med. 2012 Jul;5(7):556-60. doi: 10.1016/S1995-7645(12)60098-4.

DOI:10.1016/S1995-7645(12)60098-4

PMID:22647819

Abstract

OBJECTIVE

To evaluate the antimotility activity of Eastern Nigerian mistletoe[Loranthus micranthus (L. micranthus) Linn] parasitic on six different host trees viz. Baphia nitida, Persia americana, Kola accuminata, Irvingia gabonensis, Citrus simensis and Pentacletra macrophylla (P. mycrophylla).

METHODS

The antimotility of the methanol extracts and solvent fractions were evaluated in castor oil induced diarrheoa in rats.

RESULTS

The methanol extracts (200 mg/kg, i.p.) inhibited defeacation significantly (P < 0.05) 4 h after administration (75.73% to 93.33%) more than that of atropine sulphate (2 mg/kg, i.p.) which inhibited defeacation by 80.0%. The methanol extract (200 mg/kg, i.p.) of L. micranthus parasitic on P. mycrophylla exhibited significant (P<0.05) inhibition in gastrointestinal transit (67.6%) more than that of atropine sulphate (2 mg/kg, i.p.) which inhibited gastrointestinal transit by 26.4%. The solvent fractions of L. micranthus parasitic on P. mycrophylla at dose levels of 150 mg/kg inhibited significantly the gastrointestinal transit of mice. Fraction F(5) exhibited inhibitory activity which was comparable to loperamide (73.3%).

CONCLUSION

The methanol extract of L. micranthus parasitic on P. macrophylla exhibits higher antimotility activity that other extracts. The solvent fractions could serve as source of novel antimotility agents.

摘要

目的

评估寄生在六种不同宿主树上的尼日利亚东部槲寄生[Loranthus micranthus（L. micranthus）Linn]的抗动力活性，宿主树分别为 Baphia nitida、Persia americana、Kola accuminata、Irvingia gabonensis、Citrus simensis 和 Pentacletra macrophylla（P. mycrophylla）。

方法

采用蓖麻油诱导的大鼠腹泻模型，评价甲醇提取物及溶剂馏分的抗动力活性。

结果

甲醇提取物（200 mg/kg，ip）在给药后 4 小时显著抑制排便（75.73%至 93.33%），比硫酸阿托品（2 mg/kg，ip）抑制排便（80.0%）更为有效。寄生在 P. mycrophylla 上的 L. micranthus 的甲醇提取物（200 mg/kg，ip）在胃肠道转运方面表现出显著的抑制作用（67.6%），比硫酸阿托品（2 mg/kg，ip）抑制胃肠道转运（26.4%）更为有效。寄生在 P. mycrophylla 上的 L. micranthus 的溶剂馏分在 150 mg/kg 的剂量水平下显著抑制了小鼠的胃肠道转运。馏分 F(5)表现出与洛哌丁胺（73.3%）相当的抑制活性。