Gresser I, Maury C, Kress C, Blangy D, Maunoury M T
Int J Cancer. 1979 Aug;24(2):178-83. doi: 10.1002/ijc.2910240209.
We have determined the effect of a single injection of potent sheep anti-mouse interferon globulin on polyoma-virus-induced early runting disease and tumor formation in Swiss mice. When newborn mice were injected with greater than or equal to 9 X 10(6) PFU of polyoma virus, 16% (7/44) of mice runted and died in contrast to 96% (45/47) of mice injected with virus and anti-interferon globulin. Likewise, a greater percentage of mice injected with lower doses of virus and anti-interferon globulin developed tumors than did control virus-injected mice. These results suggest that interferon is an important factor in determining the susceptibility of newborn mice to polyoma virus.
我们已经确定了单次注射强效羊抗小鼠干扰素球蛋白对多瘤病毒诱导的瑞士小鼠早期发育迟缓疾病和肿瘤形成的影响。当新生小鼠注射大于或等于9×10⁶ 多瘤病毒空斑形成单位（PFU）时，16%（7/44）的小鼠发育迟缓并死亡，相比之下，注射病毒和抗干扰素球蛋白的小鼠中这一比例为96%（45/47）。同样，注射较低剂量病毒和抗干扰素球蛋白的小鼠中发生肿瘤的比例高于注射病毒的对照小鼠。这些结果表明，干扰素是决定新生小鼠对多瘤病毒易感性的一个重要因素。
