抗干扰素球蛋白可抑制出生时感染淋巴细胞性脉络丛脑膜炎病毒的小鼠肾小球肾炎的发展。
Anti-interferon globulin inhibits the development of glomerulonephritis in mice infected at birth with lymphocytic choriomeningitis virus.
作者信息
Gresser J, Morel-Maroger L, Verroust P, Rivière Y, Guillon J C
出版信息
Proc Natl Acad Sci U S A. 1978 Jul;75(7):3413-6. doi: 10.1073/pnas.75.7.3413.
Abstract
Swiss mice infected at birth with lymphocytic choriomeningitis virus develop glomerulonephritis. Injection of potent anti-mouse interferon globulin at the time of viral infection inhibited the development of these renal lesions. We conclude that the production of endogenous interferon by this virus in the first few days of life plays an important role in the pathogenesis of this glomerulonephritis.
摘要
出生时感染淋巴细胞性脉络丛脑膜炎病毒的瑞士小鼠会患上肾小球肾炎。在病毒感染时注射强效抗小鼠干扰素球蛋白可抑制这些肾脏病变的发展。我们得出结论，该病毒在生命最初几天产生的内源性干扰素在这种肾小球肾炎的发病机制中起重要作用。
Zotero 插件