Nakhostine M, Gershuni D H, Anderson R, Danzig L A, Weiner G M
Division of Orthopaedics and Rehabilitation, Veterans Administration Medical Center, San Diego, CA 92161.
Arthroscopy. 1990;6(4):280-7. doi: 10.1016/0749-8063(90)90057-k.
This study was designed to test the hypothesis that abrasion of the parameniscal synovium aids healing of a stable tear in the avascular region of the meniscus in a sheep model. In six sheep, a 5-7-mm longitudinal full-thickness tear was made in the avascular inner half of the anterior part of the lateral meniscus. The parameniscal synovium was abraded superiorly and inferiorly from the meniscus periphery to the lesion. Three animals in a control group received identical meniscal tears but no abrasion treatment. A harness prevented weight bearing and maintained the knee fully flexed after surgery. Twelve weeks after the operation, no healing was seen in any tears. Histologic examination revealed in both groups increased numbers of dividing chondrocytes on either side of the tear. In the test group, several layers of fibroblasts, which appeared in two menisci to derive from the upper meniscal surface, were seen covering both cut surfaces of the tear. It is concluded that the distance from the periphery to the defect is too far for abrasion therapy to stimulate sufficient cellular ingrowth to facilitate repair of tears in the avascular region of the meniscus.
在绵羊模型中，半月板周围滑膜的磨损有助于半月板无血管区域稳定撕裂的愈合。对6只绵羊的外侧半月板前部无血管的内侧半部分制造了一个5 - 7毫米长的全层纵向撕裂。从半月板周边到损伤处，在半月板上方和下方对半月板周围滑膜进行磨损。对照组的3只动物有相同的半月板撕裂，但未接受磨损治疗。术后使用吊带防止负重并使膝关节保持完全屈曲。术后12周，所有撕裂均未见愈合。组织学检查显示，两组撕裂两侧的分裂软骨细胞数量均增加。在试验组中，在两个半月板中可见几层成纤维细胞覆盖撕裂的两个断面，这些成纤维细胞似乎源自半月板上表面。得出的结论是，从周边到缺损的距离太远，磨损疗法无法刺激足够的细胞向内生长以促进半月板无血管区域撕裂的修复。
