Cancer Institute/Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Am J Hematol. 2012 Aug;87(8):766-9. doi: 10.1002/ajh.23244. Epub 2012 May 31.
We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in Th1 and Th2 cytokine genes may modify the association between blood transfusion and risk of non-Hodgkin lymphoma (NHL). Compared with women without blood transfusion, women with a history of transfusion had an increased risk of NHL if they carried IL10RA (rs9610) GG genotype [odds ratio (OR) = 1.9, 95% confidence interval (CI): 1.1-3.2] or TNF (rs1800629) AG/AA genotypes (OR = 1.6, 95% CI: 0.9-2.7). We also found women with a history of transfusion had a decreased risk of NHL if they carried IL10RA (rs9610) AG/AA genotypes (OR = 0.6, 95% CI: 0.4-0.9) or TNF (rs1800629) GG genotype (OR = 0.7, 95% CI: 0.5-1.0). A similar pattern was also observed for B-cell lymphoma but not for T-cell lymphoma. Statistically significant interactions with blood transfusion were observed for IL10RA (rs9610) (P(forinteraction) = 0.003) and TNF (rs1800629) (P(forinteraction) = 0.012) for NHL overall and IL10RA (rs9610) (P(forinteraction) = 0.001) and TNF (rs1800629) (P(forinteraction) = 0.019) for B-cell lymphoma. The results suggest that genetic polymorphisms in TNF and IL10RA genes may modify the association between blood transfusion and NHL risk.
我们在康涅狄格州的女性中进行了一项基于人群的病例对照研究，以检验以下假设：Th1 和 Th2 细胞因子基因的遗传变异可能会改变输血与非霍奇金淋巴瘤（NHL）风险之间的关联。与没有输血史的女性相比，如果携带白细胞介素 10 受体 A 基因（rs9610）GG 基因型[比值比（OR）=1.9，95%置信区间（CI）：1.1-3.2]或肿瘤坏死因子（rs1800629）AG/AA 基因型（OR=1.6，95%CI：0.9-2.7），有输血史的女性患 NHL 的风险增加。我们还发现，如果携带白细胞介素 10 受体 A 基因（rs9610）AG/AA 基因型[比值比（OR）=0.6，95%置信区间（CI）：0.4-0.9]或肿瘤坏死因子（rs1800629）GG 基因型[比值比（OR）=0.7，95%置信区间（CI）：0.5-1.0]，有输血史的女性患 NHL 的风险降低。同样的模式也存在于 B 细胞淋巴瘤中，但不存在于 T 细胞淋巴瘤中。白细胞介素 10 受体 A 基因（rs9610）（P（交互作用）=0.003）和肿瘤坏死因子（rs1800629）（P（交互作用）=0.012）与 TNF 之间存在统计学显著的相互作用，用于 NHL 总体和白细胞介素 10 受体 A 基因（rs9610）（P（交互作用）=0.001）和肿瘤坏死因子（rs1800629）（P（交互作用）=0.019）用于 B 细胞淋巴瘤。结果表明，TNF 和 IL10RA 基因的遗传多态性可能会改变输血与 NHL 风险之间的关联。
