Wu Xianrui, Zou Yifeng, He Xiaosheng, Yuan Ruixue, Chen Yufeng, Lan Nan, Lian Lei, Wang Fengwei, Fan Xinjuan, Zeng Yang, Ke Jia, Wu Xiaojian, Lan Ping
Sun Yat-sen University, Guangzhou City, Guangdong Province, P R China.
Int J Surg Pathol. 2013 Apr;21(2):111-20. doi: 10.1177/1066896912448836. Epub 2012 May 30.
The purpose of this study is to investigate the clinical/prognostic significance of tumor-infiltrating mast cells (TIMs) in patients with colorectal cancer (CRC). TIM infiltration in 325 stage I to III CRC specimens was detected by immunohistochemistry. The optimal cutpoint of TIM density was assessed by the X-tile program. TIM infiltration in CRC was significantly higher than in normal colorectal tissues. According to the X-tile program, the cutpoint for high TIM infiltration in CRC was determined when TIM density was more than 8.0 per high-power field. Correlation analysis between TIM density and clinicopathological variables demonstrated that TIM infiltration was significantly associated with gender, nodal status, and American Joint Committee on Cancer stage. Multivariate Cox regression analysis showed that high TIM infiltration was a risk factor for both overall survival and disease-free survival. Taken together, high TIM infiltration can be an independent and useful biomarker for predicting the poor survival of patients with CRC.
本研究的目的是探讨肿瘤浸润肥大细胞（TIMs）在结直肠癌（CRC）患者中的临床/预后意义。通过免疫组织化学检测了325例I至III期CRC标本中的TIM浸润情况。采用X-tile程序评估TIM密度的最佳切点。CRC中TIM浸润明显高于正常结直肠组织。根据X-tile程序，当TIM密度高于每高倍视野8.0时，确定CRC中TIM高浸润的切点。TIM密度与临床病理变量之间的相关性分析表明，TIM浸润与性别、淋巴结状态和美国癌症联合委员会分期显著相关。多因素Cox回归分析显示，TIM高浸润是总生存期和无病生存期的危险因素。综上所述，TIM高浸润可作为预测CRC患者不良生存的独立且有用的生物标志物。
