Division of Hepatology, Loyola University Medical Center, Maywood, IL, USA.
Department of Internal Medicine, UCLA Ronald Reagan Medical Center, Los Angeles, CA, USA.
Clin J Gastroenterol. 2021 Feb;14(1):1-13. doi: 10.1007/s12328-020-01281-7. Epub 2020 Nov 4.
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an uncommon and under-recognized immune-mediated disorder of the peripheral nervous system. It is associated with both infectious and non-infectious etiologies and presents in several variant forms. In rare instances, CIDP has been reported in association with gastrointestinal (esophageal, hepatic, colorectal, and pancreatic) malignancies. The diagnosis of malignancy is typically preceded by weeks to months by that of CIDP, though the inverse may also be seen. As with other etiologies of CIDP, cases associated with gastrointestinal malignancies are often treated with corticosteroids, intravenous immunoglobulins, and/or plasma exchange, with improvement or resolution of neurological symptoms in the majority of cases. In this review, we provide a practical overview of CIDP, with an emphasis on recognizing the clinical association between CIDP and gastrointestinal malignancies.
慢性炎症性脱髓鞘性多发性神经病（CIDP）是一种罕见且未被充分认识的周围神经系统免疫介导疾病。它与感染和非感染病因有关，并以几种变体形式出现。在极少数情况下，CIDP 与胃肠道（食管、肝、结直肠和胰腺）恶性肿瘤有关。恶性肿瘤的诊断通常先于 CIDP 数周至数月，但也可能出现相反的情况。与 CIDP 的其他病因一样，与胃肠道恶性肿瘤相关的病例通常用皮质类固醇、静脉注射免疫球蛋白和/或血浆置换治疗，大多数病例的神经症状改善或消退。在这篇综述中，我们提供了 CIDP 的实用概述，重点是认识到 CIDP 与胃肠道恶性肿瘤之间的临床关联。
