Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences.
Acta Naturae. 2011 Apr;3(2):34-55.
Functionalized gold nanoparticles with controlled geometrical and optical properties are the subject of intensive studies and biomedical applications, including genomics, biosensorics, immunoassays, clinical chemistry, laser phototherapy of cancer cells and tumors, the targeted delivery of drugs, DNA and antigens, optical bioimaging and the monitoring of cells and tissues with the use of state-of-the-art detection systems. This work will provide an overview of the recent advances and current challenges facing the biomedical application of gold nanoparticles of various sizes, shapes, and structures. The review is focused on the application of gold nanoparticle conjugates in biomedical diagnostics and analytics, photothermal and photodynamic therapies, as a carrier for delivering target molecules, and on the immunological and toxicological properties. Keeping in mind the huge volume and high speed of the data update rate, 2/3 of our reference list (certainly restricted to 250 Refs.) includes publications encompassing the past 5 years.
具有可控几何和光学性质的功能化金纳米粒子是密集研究和生物医学应用的主题，包括基因组学、生物传感器、免疫分析、临床化学、癌细胞和肿瘤的激光光疗、药物、DNA 和抗原的靶向递送、光学生物成像以及使用最先进的检测系统监测细胞和组织。这项工作将概述各种尺寸、形状和结构的金纳米粒子在生物医学应用中面临的最新进展和当前挑战。本综述重点介绍了金纳米粒子缀合物在生物医学诊断和分析、光热和光动力治疗、作为靶向分子载体以及免疫和毒理学特性中的应用。考虑到数据更新速度的巨大数量和高速，我们参考列表的 2/3（当然限于 250 个参考文献）包括涵盖过去 5 年的出版物。
