Alkilany Alaaldin M, Murphy Catherine J
Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801 USA.
J Nanopart Res. 2010 Sep;12(7):2313-2333. doi: 10.1007/s11051-010-9911-8. Epub 2010 Apr 6.
Gold nanoparticles have attracted enormous scientific and technological interest due to their ease of synthesis, chemical stability, and unique optical properties. Proof-of-concept studies demonstrate their biomedical applications in chemical sensing, biological imaging, drug delivery, and cancer treatment. Knowledge about their potential toxicity and health impact is essential before these nanomaterials can be used in real clinical settings. Furthermore, the underlying interactions of these nanomaterials with physiological fluids is a key feature of understanding their biological impact, and these interactions can perhaps be exploited to mitigate unwanted toxic effects. In this Perspective we discuss recent results that address the toxicity of gold nanoparticles both in vitro and in vivo, and we provide some experimental recommendations for future research at the interface of nanotechnology and biological systems.
金纳米颗粒因其易于合成、化学稳定性和独特的光学性质而引起了巨大的科技关注。概念验证研究证明了它们在化学传感、生物成像、药物递送和癌症治疗等生物医学领域的应用。在这些纳米材料能够用于实际临床环境之前，了解它们的潜在毒性和对健康的影响至关重要。此外，这些纳米材料与生理流体之间的潜在相互作用是理解其生物学影响的关键特征，并且这些相互作用或许可以被利用来减轻不良的毒性效应。在这篇观点文章中，我们讨论了近期关于金纳米颗粒体外和体内毒性的研究结果，并为纳米技术与生物系统交叉领域的未来研究提供了一些实验建议。
