Koziol Magdalena J, Gurdon John B
Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.
Biochem Res Int. 2012;2012:105203. doi: 10.1155/2012/105203. Epub 2012 May 9.
The translationally controlled tumor protein (TCTP) is highly conserved among animal species. It is widely expressed in many different tissues. It is involved in regulating many fundamental processes, such as cell proliferation and growth, apoptosis, pluripotency, and the cell cycle. Hence, it is not surprising that it is essential for normal development and, if misregulated, can lead to cancer. Provided herein is an overview of the diverse functions of TCTP, with a focus on development. Furthermore, we discuss possible ways by which TCTP misregulation or mutation could result in cancer.
翻译调控肿瘤蛋白（TCTP）在动物物种中高度保守。它在许多不同组织中广泛表达。它参与调节许多基本过程，如细胞增殖与生长、细胞凋亡、多能性和细胞周期。因此，它对正常发育至关重要，如果调控失调会导致癌症也就不足为奇了。本文概述了TCTP的多种功能，重点是发育。此外，我们还讨论了TCTP调控失调或突变可能导致癌症的几种可能方式。
