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紫檀芪可延长雌雄两性的平均寿命，通过调节两性不同蛋白实现。

Pterostilbene Promotes Mean Lifespan in Both Male and Female Modulating Different Proteins in the Two Sexes.

机构信息

School of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III da Varano, 62032 Camerino (MC), Italy.

Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.

出版信息

Oxid Med Cell Longev. 2022 Feb 16;2022:1744408. doi: 10.1155/2022/1744408. eCollection 2022.

DOI:10.1155/2022/1744408
PMID:35222791
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8865974/
Abstract

Aging is a multifactorial phenomenon characterized by degenerative processes closely connected to oxidative damage and chronic inflammation. Recently, many studies have shown that natural bioactive compounds are useful in delaying the aging process. In this work, we studied the effects of an supplementation of the stilbenoid pterostilbene on lifespan extension in . We found that the average lifespan of flies of both sexes was increased by pterostilbene supplementation with a higher effect in females. The expression of longevity related genes (Sir2, Foxo, and Notch) was increased in both sexes but with different patterns. Pterostilbene counteracted oxidative stress induced by ethanol and paraquat and up-regulated the antioxidant enzymes Ho e Trxr-1 in male but not in female flies. On the other hand, pterostilbene decreased the inflammatory mediators dome and egr only in female flies. Proteomic analysis revealed that pterostilbene modulates 113 proteins in male flies and only 9 in females. Only one of these proteins was modulated by pterostilbene in both sexes: vacuolar H[+] ATPase 68 kDa subunit 2 (Vha68-2) that was strongly down-regulated. These findings suggest a potential role of pterostilbene in increasing lifespan both in male and female flies by mechanisms that seem to be different in the two sexes, highlighting the need to conduct nutraceutical supplementation studies on males and females separately in order to give more reliable results.

摘要

衰老是一种多因素现象，其特征是与氧化损伤和慢性炎症密切相关的退行性过程。最近，许多研究表明，天然生物活性化合物可用于延缓衰老过程。在这项工作中，我们研究了补充白藜芦醇对 寿命延长的影响。我们发现，白藜芦醇补充剂可延长雌雄蝇的平均寿命，对雌性蝇的影响更高。长寿相关基因（Sir2、Foxo 和 Notch）在雌雄蝇中均有表达增加，但模式不同。白藜芦醇可抵抗乙醇和百草枯引起的氧化应激，并上调雄性蝇中的抗氧化酶 Ho 和 Trxr-1，但对雌性蝇无作用。另一方面，白藜芦醇仅在雌性蝇中降低炎症介质 dome 和 egr。蛋白质组学分析显示，白藜芦醇可调节雄性蝇中的 113 种蛋白质，而仅调节雌性蝇中的 9 种蛋白质。只有一种蛋白质在雌雄蝇中均受白藜芦醇调节：液泡 H[+]ATP 酶 68kDa 亚基 2（Vha68-2），其表达被强烈下调。这些发现表明，白藜芦醇可能通过在两性中似乎不同的机制来增加雌雄蝇的寿命，这突出表明需要分别对男性和女性进行营养补充研究，以获得更可靠的结果。

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