Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center Houston, TX, USA.
Front Oncol. 2012 Jan 31;2:5. doi: 10.3389/fonc.2012.00005. eCollection 2012.
Ubiquitination has been demonstrated to play a pivotal role in multiple biological functions, which include cell growth, proliferation, apoptosis, DNA damage response, innate immune response, and neuronal degeneration. Although the role of ubiquitination in targeting proteins for proteasome-dependent degradation have been extensively studied and well-characterized, the critical non-proteolytic functions of ubiquitination, such as protein trafficking and kinase activation, involved in cell survival and cancer development, just start to emerge, In this review, we will summarize recent progresses in elucidating the non-proteolytic function of ubiquitination signaling in protein kinase activation and its implications in human cancers. The advancement in the understanding of the novel functions of ubiquitination in signal transduction pathways downstream of growth factor receptors may provide novel paradigms for the treatment of human cancers.
泛素化在多种生物学功能中发挥着关键作用，包括细胞生长、增殖、凋亡、DNA 损伤反应、先天免疫反应和神经元退化。虽然泛素化在靶向蛋白质进行蛋白酶体依赖性降解中的作用已经得到了广泛的研究和充分的描述，但泛素化的关键非蛋白水解功能，如参与细胞存活和癌症发展的蛋白质运输和激酶激活，才刚刚开始显现。在这篇综述中，我们将总结阐明泛素化信号在蛋白激酶激活中非蛋白水解功能及其在人类癌症中的意义的最新进展。对生长因子受体下游信号转导途径中泛素化的新功能的理解的进展，可能为人类癌症的治疗提供新的范例。
