良性脑肿瘤亚型与胶质瘤的癌症家族史。
Family history of cancer in benign brain tumor subtypes versus gliomas.
机构信息
Department of Anthropology, Case Western Reserve University Cleveland, OH, USA.
出版信息
Front Oncol. 2012 Feb 28;2:19. doi: 10.3389/fonc.2012.00019. eCollection 2012.
PURPOSE
Family history is associated with gliomas, but this association has not been established for benign brain tumors. Using information from newly diagnosed primary brain tumor patients, we describe patterns of family cancer histories in patients with benign brain tumors and compare those to patients with gliomas.
METHODS
Newly diagnosed primary brain tumor patients were identified as part of the Ohio Brain Tumor Study. Each patient was asked to participate in a telephone interview about personal medical history, family history of cancer, and other exposures. Information was available from 33 acoustic neuroma (65%), 78 meningioma (65%), 49 pituitary adenoma (73.1%), and 152 glioma patients (58.2%). The association between family history of cancer and each subtype was compared with gliomas using unconditional logistic regression models generating odds ratios (ORs) and 95% confidence intervals.
RESULTS
There was no significant difference in family history of cancer between patients with glioma and benign subtypes.
CONCLUSION
The results suggest that benign brain tumor may have an association with family history of cancer. More studies are warranted to disentangle the potential genetic and/or environmental causes for these diseases.
目的
家族史与神经胶质瘤有关，但尚未确定良性脑瘤与之相关。本研究利用新诊断的原发性脑肿瘤患者的信息，描述了良性脑瘤患者的家族癌症史模式，并将其与神经胶质瘤患者进行了比较。
方法
作为俄亥俄脑肿瘤研究的一部分，确定了新诊断的原发性脑肿瘤患者。每位患者都被要求参加一次关于个人病史、癌症家族史和其他暴露情况的电话访谈。可从 33 例听神经瘤（65%）、78 例脑膜瘤（65%）、49 例垂体腺瘤（73.1%）和 152 例神经胶质瘤患者（58.2%）中获得信息。使用非条件逻辑回归模型生成比值比（OR）和 95%置信区间，比较癌症家族史与每种亚型之间的关联。
结果
胶质瘤患者与良性肿瘤患者的癌症家族史无显著差异。
结论
结果表明，良性脑瘤可能与癌症家族史有关。需要进一步的研究来阐明这些疾病的潜在遗传和/或环境原因。
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