Liu Chun-Ling, Guo Bo, Zhang Xue-Jin, Lü Hong-Bin, Tang Li, Luo Qing-Li
Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2012 Mar;43(2):180-2.
To investigate the expression of CC chemokine receptor 1(CCR1) on the immune cells in orbital tissue of patients with thyroid associated ophthalmopathy(TAO).
The tissue samples of orbital tissue were collected from 25 cases of TAO patient and 10 normal control subjects, and the expression of CCR1 in the immune cells was studied by SP immunohistochemistry. The correlation between CCR1 and clinical activity scores (GAS) was analyzed.
The expression of CCR1 on immune cells was positive, in orbital tissue of patients with TAO, and the positive rate was 84%, while it was negative or low positive in normal control subjects. The difference between them was significant (P < 0.05). In addition, the expression of CCR1 on the immune cells of orbital tissue with TAO had significant correlation with CAS (P < 0.05).
The expression of chemokine receptor CCR1 on the immune cells in orbital tissue of TAO patients is higher than that of normal subjects. CCR1 may play a role in the pathogenesis of TAO.
探讨CC趋化因子受体1（CCR1）在甲状腺相关眼病（TAO）患者眼眶组织免疫细胞中的表达。
收集25例TAO患者及10例正常对照者的眼眶组织样本，采用SP免疫组织化学法研究免疫细胞中CCR1的表达情况，并分析CCR1与临床活动度评分（GAS）的相关性。
TAO患者眼眶组织免疫细胞中CCR1表达呈阳性，阳性率为84%，而正常对照者为阴性或弱阳性，两者差异有统计学意义（P<0.05）。此外，TAO眼眶组织免疫细胞中CCR1的表达与CAS有显著相关性（P<0.05）。
TAO患者眼眶组织免疫细胞中趋化因子受体CCR1的表达高于正常受试者。CCR1可能在TAO发病机制中起作用。
