[趋化因子受体1在甲状腺相关眼病眼眶成纤维细胞中的表达]
[Expression of CCR1 in the orbital fibroblasts with thyroid associated ophthalmopathy].
作者信息
Liu Chun-Ling, Zhang Xue-Jin, Guo Bo, Yang Jun-Feng, Luo Qing-Li
机构信息
Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China.
出版信息
Sichuan Da Xue Xue Bao Yi Xue Ban. 2011 Sep;42(5):630-2.
OBJECTIVE
To investigate the expression of chemokine receptor (CCR1) in the orbital fibroblasts (OFs) with thyroid associated ophthalmopathy (TAO) and to explore the pathogenesis of TAO.
METHODS
By immunohistochemistry, the expression of CCR1 was studied in 25 cases of TAO patients and 10 normal control subjects and the correlation between CCR1 and GAS was analysed.
RESULTS
The expression of CCR1 in the OFs with TAO was positive, but it was negative or weak positive in normal control subjects. The difference between them was significant (P < 0.05). And the expression of CCR1 in the OFs with TAO had no significant correlation with GAS (r = 0. 048, P > 0.05).
CONCLUSION
The expression of chemokine receptor CCR1 is higher on OFs of TAO patients than that of normal subjects. CCR1 maybe play a role in pathogenesis of TAO.
目的
研究趋化因子受体（CCR1）在甲状腺相关性眼病（TAO）眼眶成纤维细胞（OFs）中的表达情况，探讨TAO的发病机制。
方法
采用免疫组织化学法，研究25例TAO患者及10例正常对照者眼眶成纤维细胞中CCR1的表达情况，并分析CCR1与突眼度（GAS）的相关性。
结果
TAO患者眼眶成纤维细胞中CCR1表达呈阳性，而正常对照者眼眶成纤维细胞中CCR1表达为阴性或弱阳性。两者差异有统计学意义（P < 0.05）。TAO患者眼眶成纤维细胞中CCR1表达与突眼度无明显相关性（r = 0. 048，P > 0.05）。
结论
TAO患者眼眶成纤维细胞趋化因子受体CCR1表达高于正常对照者，CCR1可能在TAO发病机制中发挥作用。
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