来自羊角拗的两个新的鸟笼型海南粗榧烷型生物碱维罗沙因 A 和 B，具有前所未有的骨架。

Virosaines A and B, two new birdcage-shaped Securinega alkaloids with an unprecedented skeleton from Flueggea virosa.

机构信息

Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.

出版信息

Org Lett. 2012 Jun 15;14(12):3096-9. doi: 10.1021/ol301184j. Epub 2012 May 31.

DOI:10.1021/ol301184j

PMID:22650148

Abstract

Two new Securinega alkaloids, virosaines A (1) and B (2), were isolated from the twigs and leaves of Flueggea virosa. The structures and absolute configurations were elucidated by means of NMR, X-ray diffraction, and CD analyses. Compounds 1 and 2 represent the first examples of Securinega alkaloids bearing a 7-oxa-1-azabicyclo[3.2.1]octane ring system, whose plausible biogenetic pathways were also proposed.

摘要

从黄瑞木的嫩枝和叶子中分离得到了两个新的 Securinega 生物碱，维罗沙因 A（1）和 B（2）。通过 NMR、X 射线衍射和 CD 分析阐明了它们的结构和绝对构型。化合物 1 和 2 代表了第一个具有 7-氧代-1-氮杂双环[3.2.1]辛烷环系统的 Securinega 生物碱的例子，同时也提出了它们可能的生物合成途径。