Gan Li-She, Fan Cheng-Qi, Yang Sheng-Ping, Wu Yan, Lin Li-Ping, Ding Jian, Yue Jian-Min
State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Zhangjiang Hi-Tech Park, PR China.
Org Lett. 2006 May 25;8(11):2285-8. doi: 10.1021/ol060551f.
[structure: see text] Two unprecedented C,C-linked dimeric indolizidine alkaloids, flueggenines A (1) and B (2), as well as their biosynthetic precursor (-)-norsecurinine, were isolated from the roots of Flueggea virosa. Their structures and absolute configurations were elucidated by spectroscopic methods, especially 2D NMR and CD spectral analyses, and supported by their unique biosynthetic pathway as proposed. Both 1 and 2 were tested against two tumor cell lines, and alkaloid 1 showed weak activity against the P-388 cell line.
[结构：见正文] 从白饭树的根部分离出了两种前所未有的碳-碳相连的二聚吲哚里西啶生物碱，flueggenines A（1）和B（2），以及它们的生物合成前体（-）-降一叶萩碱。通过光谱方法，特别是二维核磁共振和圆二色光谱分析，阐明了它们的结构和绝对构型，并得到了所提出的独特生物合成途径的支持。对1和2都针对两种肿瘤细胞系进行了测试，生物碱1对P-388细胞系显示出微弱的活性。
