Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou 510632, People's Republic of China.
Org Lett. 2011 Aug 5;13(15):3888-91. doi: 10.1021/ol201410z. Epub 2011 Jul 5.
Two unprecedented C,C-linked dimeric indolizidine alkaloids, flueggines A (1) and B (2), were isolated from the twigs and leaves of Flueggea virosa. The structures and absolute configurations were elucidated by means of NMR, single-crystal X-ray diffraction, and CD analyses. Compound 1 is the first example of Securinega alkaloids bearing an isoxazolidine ring, the plausible biogenetic pathway of which is also proposed. Compound 2 exhibited growth inhibitory activity against MCF-7 and MDA-MB-231 human breast cancer cells.
从 Flueggea virosa 的小枝和叶子中分离得到了两个前所未有的 C,C-连接的二聚吲哚里西啶生物碱，分别为 flueggines A（1）和 B（2）。通过 NMR、单晶 X 射线衍射和 CD 分析阐明了它们的结构和绝对构型。化合物 1 是第一个具有异恶唑烷环的 Securinega 生物碱的例子，同时也提出了其可能的生物合成途径。化合物 2 对 MCF-7 和 MDA-MB-231 人乳腺癌细胞表现出生长抑制活性。
