Nolan A M, Reid J, Grant S
Department of Veterinary Pharmacology, University of Glasgow Veterinary School, UK.
J Vet Pharmacol Ther. 1993 Sep;16(3):335-42. doi: 10.1111/j.1365-2885.1993.tb00180.x.
The pharmacokinetics of propofol, 6.5 mg/kg, administered as a bolus dose intravenously (i.v.) were studied in six dogs (group 1). The effect of maintaining anaesthesia with halothane and nitrous oxide in oxygen on propofol pharmacokinetics was also investigated in six dogs undergoing routine anaesthesia (group 2). Induction of anaesthesia was rapid in all animals. Post-induction apnoea was a feature in three of the 12 dogs. The blood propofol concentration-time profile was best described by a bi-exponential decline in two dogs in group 1 and in 3 dogs in group 2, and by a tri-exponential decline in four dogs in group 1 and 3 dogs in group 2. The elimination half-life was long in both groups (90.9 min and 75.2 min, respectively), the volume of distribution at steady state large (4889 and 4863 ml/kg) and the clearance rapid (58.6 and 56.3 ml/kg.min). There were no significant differences between the groups, thus indicating that maintenance of anaesthesia with halothane and nitrous oxide had no effect on the pharmacokinetics of propofol in the dog.
对6只犬（第1组）静脉推注6.5mg/kg丙泊酚后的药代动力学进行了研究。还对6只接受常规麻醉的犬（第2组）研究了在氟烷和一氧化二氮-氧气混合气体维持麻醉的情况下丙泊酚药代动力学的变化。所有动物麻醉诱导均迅速。12只犬中有3只在诱导后出现呼吸暂停。第1组的2只犬和第2组的3只犬的血丙泊酚浓度-时间曲线以双指数下降最好拟合，第1组的4只犬和第2组的3只犬以三指数下降最好拟合。两组的消除半衰期均较长（分别为90.9分钟和75.2分钟），稳态分布容积较大（4889和4863ml/kg），清除率较快（58.6和56.3ml/kg·min）。两组之间无显著差异，因此表明氟烷和一氧化二氮维持麻醉对犬丙泊酚的药代动力学无影响。
