Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.
Org Lett. 2012 Jun 15;14(12):3084-7. doi: 10.1021/ol301155b. Epub 2012 May 31.
A dual-catalysis/anion-binding approach with a chiral hydrogen bonding (HB) catalyst and an achiral nucleophilic cocatalyst was applied to the kinetic resolution of amines. Out of a structurally diverse collection of 22 nucleophilic species, 4-di-n-propylaminopyridine emerged as the most efficient cocatalyst, allowing for the kinetic resolution of benzylic amines with s-factors of up to 67.
采用手性氢键（HB）催化剂和非手性亲核共催化剂的双催化/阴离子结合方法，应用于胺的动力学拆分。在所研究的 22 种亲核试剂中，4-二正丙基氨基吡啶是最有效的共催化剂，它允许苄胺以高达 67 的 s 因子进行动力学拆分。
