Shulman M, Joseph N J, Haller C A
University of Illinois Medical Center, Chicago.
Reg Anesth. 1990 May-Jun;15(3):142-6.
Three groups of dogs were each given repeat epidural injections of a 10% butamben suspension. A fourth group received a single subarachnoid injection of the butamben suspension. All dogs were later sacrificed and the spinal cord, meninges and spinal nerves were examined. The dogs receiving the epidural injections had no pathology. Those dogs that received subarachnoid injections had adhesive arachnoiditis. None demonstrated any evidence of neurolysis. Two cancer patients who had each received multiple injections of a 10% butamben suspension for the successful treatment of cancer pain prior to their deaths had autopsies and the spinal cords, meninges and spinal nerves were examined. No significant pathology due to the butamben was noted. Epidural butamben does not appear to cause any local tissue damage provided that subarachnoid needle placement has been ruled out. Subarachnoid butamben should be avoided.
将三组狗分别重复硬膜外注射10%布坦苯悬浮液。第四组接受一次蛛网膜下腔注射布坦苯悬浮液。所有狗随后被处死，并对脊髓、脑膜和脊神经进行检查。接受硬膜外注射的狗没有病理变化。接受蛛网膜下腔注射的狗患有粘连性蛛网膜炎。没有一只狗表现出任何神经松解的迹象。两名癌症患者在死亡前均接受了多次10%布坦苯悬浮液注射以成功治疗癌症疼痛，对他们进行了尸检，并检查了脊髓、脑膜和脊神经。未发现布坦苯引起的明显病理变化。只要排除了蛛网膜下腔穿刺针的误置，硬膜外注射布坦苯似乎不会引起任何局部组织损伤。应避免蛛网膜下腔注射布坦苯。
