Gozal David, Kheirandish-Gozal Leila, Bhattacharjee Rakesh, Kim Jinkwan
Department of Pediatrics, Comer Children's Hospital, Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA.
Front Biosci (Elite Ed). 2012 Jun 1;4(7):2410-22. doi: 10.2741/e553.
Obesity has emerged as one of the most important epidemics in the western hemisphere, and as its prevalence continues to increase in children, the associated risk for cardiovascular and metabolic complications follows parallel increases in prevalence, and reflects activation of underlying inflammatory pathways. The obstructive sleep apnea syndrome (OSAS) is a frequent condition in children associated with intermittent upper airway obstruction during sleep, its prevalence is markedly increased in the presence of obesity, and is associated with activation of similar inflammatory mechanisms as those activated by obesity, suggesting that the 2 disorders may reciprocally contribute to their adverse consequences. C-reactive protein (CRP) is a prototypic marker of inflammation that has repeatedly shown promise as a potentially reliable biomarker of cardiovascular morbidity. In addition, under certain circumstances CRP may enhance inflammation, oxidative stress, and pro-coagulant activity and thus promote atherogenesis. In this paper, we will critically review the available evidence linking OSAS to systemic inflammation in children using CRP levels as the reporter biomarker.
肥胖已成为西半球最重要的流行病之一。随着儿童肥胖患病率持续上升，与之相关的心血管和代谢并发症风险也随之平行增加，这反映了潜在炎症途径的激活。阻塞性睡眠呼吸暂停综合征（OSAS）在儿童中很常见，与睡眠期间间歇性上呼吸道阻塞有关。在肥胖情况下，其患病率显著增加，并且与肥胖激活的类似炎症机制有关，这表明这两种疾病可能相互促进其不良后果。C反应蛋白（CRP）是一种典型的炎症标志物，多次显示有望成为心血管疾病潜在可靠的生物标志物。此外，在某些情况下，CRP可能会增强炎症、氧化应激和促凝血活性，从而促进动脉粥样硬化的发生。在本文中，我们将以CRP水平作为报告生物标志物，严格审查将OSAS与儿童全身炎症联系起来的现有证据。
