小儿阻塞性睡眠呼吸暂停与心血管风险。
OSA and Cardiovascular Risk in Pediatrics.
机构信息
Division of Pediatric Otolaryngology-Head and Neck Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Division of Pulmonary and Sleep Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, OH.
Division of Pulmonary and Sleep Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
出版信息
Chest. 2019 Aug;156(2):402-413. doi: 10.1016/j.chest.2019.02.011. Epub 2019 Feb 18.
OSA occurs in approximately 1% to 5% of children in the United States. Long-term cardiovascular risks associated with OSA in the adult population are well documented. Although changes in BP regulation occur in children with OSA, the pathways leading to chronic cardiovascular risks of OSA in children are less clear. Risk factors associated with cardiovascular disease in adult populations could carry the same future risk for children. It is imperative to determine whether known mechanisms of cardiovascular diseases in adults are like those that lead to pediatric disease. Early pathophysiologic changes may lead to a lifetime burden of cardiovascular disease and early mortality. With this perspective in mind, our review discusses pathways leading to cardiovascular pathology in children with OSA and provides a comprehensive overview of recent research findings related to cardiovascular sequelae in the pediatric population.
阻塞性睡眠呼吸暂停（OSA）在美国约占儿童的 1% 至 5%。成人中与 OSA 相关的长期心血管风险已得到充分记录。尽管 OSA 患儿的血压调节会发生变化，但导致 OSA 患儿发生慢性心血管风险的途径尚不清楚。与成人心血管疾病相关的危险因素可能对儿童具有相同的未来风险。当务之急是确定成人心血管疾病的已知机制是否与导致儿科疾病的机制相同。早期病理生理学变化可能导致终生的心血管疾病负担和早逝。考虑到这一点，我们的综述讨论了导致 OSA 患儿心血管病理的途径，并提供了有关儿科人群心血管后果的最新研究结果的综合概述。
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