Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, China.
Front Biosci (Landmark Ed). 2012 Jun 1;17(7):2559-65. doi: 10.2741/4071.
Vascularization is crucial for tumor growth and metastasis. Angiogenesis and vasculogenesis are widely accepted processes of tumor vascularization, particularly for endothelium-dependent vessels. In both these processes, the tumor vascular endothelial cells are derived from the host cells, including cells in normal tissues around the tumor or endothelial progenitor cells. In addition, the mosaic vessels occur as a transitional pattern between endothelium-dependent vessels and vasculogenic mimicry (VM), wherein both host endothelium and tumor cells participate in tumor vascularization. VM provides a special passage not involving endothelial cells and is conspicuously different from angiogenesis and vasculogenesis. The biological features of the tumor cells that form VM remain unknown. Tumor stem cells may participate in VM. In this review, we discuss the patterns involved in the origin of vascularization in tumors.
血管生成对于肿瘤的生长和转移至关重要。血管生成和血管发生是肿瘤血管生成的广泛接受的过程，特别是对于内皮依赖性血管。在这两个过程中，肿瘤血管内皮细胞来源于宿主细胞，包括肿瘤周围正常组织中的细胞或内皮祖细胞。此外，镶嵌血管是内皮依赖性血管和血管生成拟态（VM）之间的过渡模式，其中宿主内皮细胞和肿瘤细胞都参与肿瘤血管生成。VM 提供了一种不涉及内皮细胞的特殊通道，与血管生成和血管发生明显不同。形成 VM 的肿瘤细胞的生物学特征尚不清楚。肿瘤干细胞可能参与 VM。在这篇综述中，我们讨论了肿瘤血管生成起源的相关模式。
