沉默调节蛋白3（SIRT3）与癌症特征
Sirtuin-3 (SIRT3) and the Hallmarks of Cancer.
作者信息
Alhazzazi Turki Y, Kamarajan Pachiyappan, Verdin Eric, Kapila Yvonne L
机构信息
Division of Oral Biology, Oral Basic and Clinical Sciences Department, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia ; Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
出版信息
Genes Cancer. 2013 Mar;4(3-4):164-71. doi: 10.1177/1947601913486351.
Abstract
Sirtuins (SIRT1-SIRT7), the mammalian homologs of the silent information regulator 2 (Sir2) in Saccharomyces cerevisiae, have been a major focus of study in the scientific community this past decade because of their emerging role in cancer biology and other age-related diseases. Emerging functions for this unique family of enzymes include roles in genomic stability, angiogenesis, metabolism, and anoikis. Here, we review recent developments on the role of sirtuins in cancer with a particular focus on SIRT3 and its role in the hallmarks of cancer and as a potential drug target for cancer treatment.
摘要
沉默信息调节因子2（Sir2）在酿酒酵母中的哺乳动物同源物——沉默调节蛋白（Sirtuins，SIRT1-SIRT7），在过去十年里一直是科学界研究的主要焦点，因为它们在癌症生物学和其他与年龄相关的疾病中发挥着越来越重要的作用。这类独特的酶家族的新功能包括在基因组稳定性、血管生成、新陈代谢和失巢凋亡中的作用。在这里，我们回顾了沉默调节蛋白在癌症中作用的最新进展，特别关注SIRT3及其在癌症特征中的作用以及作为癌症治疗潜在药物靶点的情况。
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