Harris Bradley J, Dalhaimer Paul
Department of Chemical and Biomolecular Engineering, University of Tennessee, Knoxville, TN 37996, USA.
Front Biosci (Schol Ed). 2012 Jun 1;4(4):1344-53. doi: 10.2741/s336.
Particles that have the potential to deliver imaging agents and drugs to cells and tissue now have many different shapes and sizes. This diversity in particle shape could provide new options for potential treatments of diseases because geometry affects biodistribution. However, the myriad of particle shapes now available increases the number of variables or parameters that must be taken into consideration for the drug delivery field to understand particle-cell interactions. This is especially true when the shape of a particle is a tunable parameter along with particle chemistry, charge, and hydrophobicity. Here we review the impact of shape on particle-cell interactions in vitro and the ramifications of different particle geometries on circulation, biodistribution, localization to tumors, and toxicology in rodents.
有潜力将成像剂和药物递送至细胞和组织的颗粒如今具有许多不同的形状和大小。颗粒形状的这种多样性可为疾病的潜在治疗提供新的选择，因为几何形状会影响生物分布。然而，现有的无数种颗粒形状增加了药物递送领域为理解颗粒与细胞相互作用而必须考虑的变量或参数的数量。当颗粒的形状与颗粒化学性质、电荷和疏水性一样是一个可调参数时，情况尤其如此。在此，我们综述了形状对体外颗粒与细胞相互作用的影响，以及不同颗粒几何形状对啮齿动物体内循环、生物分布、肿瘤定位和毒理学的影响。
