The University of Texas at Austin, Department of Biomedical Engineering, 1 University Station, C0800, Austin, TX 78712-0238, USA.
Expert Opin Drug Deliv. 2010 Apr;7(4):479-95. doi: 10.1517/17425240903579971.
Although significant progress has been made in delivering therapeutic agents through micro and nanocarriers, precise control over in vivo biodistribution and disease-responsive drug release has been difficult to achieve. This is critical for the success of next generation drug delivery devices, as newer drugs, designed to interfere with cellular functions, must be efficiently and specifically delivered to diseased cells. The chief constraint in achieving this has been our limited repertoire of particle synthesis methods, especially at the nanoscale. Recent developments in generating shape-specific nanocarriers and the potential to combine stimuli-responsive release with nanoscale delivery devices show great promise in overcoming these limitations.
How recent advances in fabrication technology allow synthesis of highly monodisperse, stimuli-responsive, drug-carrying nanoparticles of precise geometries is discussed. How particle properties, specifically shape and stimuli responsiveness, affect biodistribution, cellular uptake and drug release is also reviewed.
The reader is introduced to recent developments in intelligent drug nanocarriers and new nanofabrication approaches that can be combined with disease-responsive biomaterials. This will provide insight into the importance of controlling particle geometry and incorporating stimuli-responsive materials into drug delivery.
The integration of responsive biomaterials into shape-specific nanocarriers is one of the most promising avenues towards the development of next generation, advanced drug delivery systems.
虽然通过微纳米载体输送治疗剂已经取得了重大进展，但对体内生物分布和疾病响应性药物释放的精确控制一直难以实现。这对于下一代药物输送装置的成功至关重要，因为旨在干扰细胞功能的新型药物必须有效地和有针对性地递送到病变细胞。实现这一目标的主要限制是我们有限的颗粒合成方法，特别是在纳米尺度上。最近在生成具有特定形状的纳米载体方面的进展以及将响应性释放与纳米尺度输送装置相结合的潜力，为克服这些限制带来了巨大的希望。
讨论了最近制造技术的进步如何允许合成具有高度单分散性、响应性、载药纳米颗粒的精确几何形状。还讨论了颗粒特性，特别是形状和响应性，如何影响生物分布、细胞摄取和药物释放。
读者将了解智能药物纳米载体和新的纳米制造方法的最新进展，这些方法可以与响应疾病的生物材料相结合。这将深入了解控制颗粒几何形状和将响应性材料纳入药物输送的重要性。
将响应性生物材料整合到具有特定形状的纳米载体中是开发下一代先进药物输送系统的最有前途的途径之一。
