在渥太华斑贴试验诊所进行的对苯二胺过敏和相关对氨基化合物的 10 年回顾。
A 10-year review of p-phenylenediamine allergy and related para-amino compounds at the Ottawa Patch Test Clinic.
机构信息
Department of Dermatology, University of Ottawa, 1053 Carling Ave., Ottawa, Ontario, Canada.
出版信息
Dermatitis. 2011 Nov-Dec;22(6):332-4. doi: 10.2310/6620.2011.11044.
BACKGROUND
p-Phenylenediamine (PPD) is an important allergen; 5.0% of patients tested positive to PPD when patch-tested, according to the North American Contact Dermatitis Group. Hair dyes are the main source of exposure.
OBJECTIVE
To assess the significance of PPD allergy at the Ottawa Patch Test Clinic.
METHODS
We assessed the epidemiology of PPD allergies and determined the cross-reactivity with other para-amino compounds. Charts of patients visiting the Ottawa Patch Test Clinic between May 1997 and July 2009 were reviewed.
RESULTS
One hundred thirty-four patients were found to have a contact allergy to PPD; 75.4% were female, 24.6% were male, 13.4% were hairdressers, 18.7% had a history of atopy, 90.3% were sensitized by hair dye, 2.2% were sensitized by henna tattoos, and 7.5% were sensitized by other sources. Positive patch-test reactions to textile dyes were seen in 24.6%, 7.5% reacted to benzocaine, 6.0% reacted to sulfa drugs, 1.5% reacted to isopropyl-para-phenylenediamine, and 1.5% reacted to para-aminobenzoic acid.
CONCLUSIONS
PPD is an important source of allergic contact allergy. Our results show a significant relationship of PPD with other related para-amino compounds.
背景
对苯二胺（PPD）是一种重要的过敏原；根据北美接触性皮炎组的数据，5.0%的接受斑贴试验的患者对 PPD 呈阳性。染发剂是接触 PPD 的主要来源。
目的
评估渥太华斑贴试验诊所中 PPD 过敏的意义。
方法
我们评估了 PPD 过敏的流行病学，并确定了与其他对氨基化合物的交叉反应性。回顾了 1997 年 5 月至 2009 年 7 月期间在渥太华斑贴试验诊所就诊的患者图表。
结果
发现 134 例患者对 PPD 有接触过敏；75.4%为女性，24.6%为男性，13.4%为理发师，18.7%有特应性病史，90.3%由染发剂致敏，2.2%由指甲花纹身致敏，7.5%由其他来源致敏。24.6%对纺织品染料呈阳性斑贴试验反应，7.5%对苯佐卡因有反应，6.0%对磺胺类药物有反应，1.5%对异丙基-对苯二胺有反应，1.5%对对氨基苯甲酸有反应。
结论
PPD 是一种重要的过敏性接触过敏原。我们的结果表明 PPD 与其他相关的对氨基化合物之间存在显著关系。
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