Division of Dermatology, McGill University Health Centre, Montréal, Quebec, Canada.
Dermatitis. 2012 Jan-Feb;23(1):6-16. doi: 10.1097/DER.0b013e31823d1b81.
Acrylates are plastic materials that are formed by the polymerization of monomers derived from acrylic or methacrylic acid. They have found numerous applications in paints, varnishes and adhesives, in the printing industry, in the medical and dental professions, and in artificial nails. Beginning in the 1950s, many reports of occupational and nonoccupational allergic contact dermatitis to (meth)acrylate monomers have been published. These molecules are strong irritants, and patch testing can induce active sensitization. When patch tested, acrylate-allergic patients often display multiple positive tests. These reactions may represent cross-reactions, or concomitant reactions due to the presence, in the products responsible for sensitization, of impurities not disclosed in material safety data sheets. (Meth)acrylates are volatile and unstable chemicals, as demonstrated by their rapid disappearance from commercially available patch test allergens when exposed to air for more than a few hours.
丙烯酸酯是由丙烯酸或甲基丙烯酸衍生的单体聚合而成的塑料材料。它们在油漆、清漆和粘合剂、印刷业、医疗和牙科行业以及人造指甲中都有广泛的应用。自 20 世纪 50 年代以来，已经有许多关于职业性和非职业性过敏性接触性皮炎的报道。这些分子是强烈的刺激物，斑贴试验会导致主动致敏。当进行斑贴试验时，丙烯酸酯过敏的患者通常会显示出多个阳性试验。这些反应可能是交叉反应，也可能是由于在导致致敏的产品中存在未在材料安全数据表中披露的杂质所致的伴随反应。（甲基）丙烯酸酯是挥发性和不稳定的化学物质，当暴露在空气中数小时以上时，它们会从市售的斑贴试验变应原中迅速消失，这一点已经得到了证明。
