Gmünder F K, Joller P W, Joller-Jemelka H I, Bechler B, Cogoli M, Ziegler W H, Müller J, Aeppli R E, Cogoli A
Institute of Biotechnology, Swiss Federal Institute of Technology, Zurich.
Br J Sports Med. 1990 Jun;24(2):103-12. doi: 10.1136/bjsm.24.2.103.
The effect of a food supplement on immunological parameters of 16 long-distance runners was tested in a randomized, double-blind and placebo-controlled trial. The supplement comprised plasmolysed herbal yeast, malt, honey, and orange juice. No statistically significant differences between the two groups regarding the following variables were detected at three sessions at rest and immediately after a 21 km run: total and differential white blood cell counts, numbers of B- and T-cells and T-subpopulations, concanavalin-A-induced lymphocyte proliferation, serum levels of immunoglobulins, neopterin, IL-2 receptors, beta 2-microglobulin, complement factor b, c4 and c3c, and c1-inactivator. These findings suggest that the effects of the tested food supplement on these parameters are negligible with respect to improvements in the immunological status of long-distance runners. The changes observed immediately after the run had a transient character. In both groups, however, low lymphocyte counts, IgG subclass 2 levels and c1-inactivator levels were noted at rest, which indicate that the immune status of endurance athletes may be affected by training.
在一项随机、双盲、安慰剂对照试验中，测试了一种食品补充剂对16名长跑运动员免疫参数的影响。该补充剂包含质壁分离的草本酵母、麦芽、蜂蜜和橙汁。在三个静息时段以及21公里跑步后即刻，两组在以下变量方面未检测到统计学显著差异：白细胞总数及分类计数、B细胞和T细胞数量及T亚群、伴刀豆球蛋白A诱导的淋巴细胞增殖、免疫球蛋白、新蝶呤、白细胞介素-2受体、β2-微球蛋白、补体因子b、c4和c3c以及c1-灭活剂的血清水平。这些发现表明，就改善长跑运动员的免疫状态而言，所测试的食品补充剂对这些参数的影响可忽略不计。跑步后即刻观察到的变化具有短暂性。然而，在两组中，静息时均注意到淋巴细胞计数、IgG 2亚类水平和c1-灭活剂水平较低，这表明耐力运动员的免疫状态可能受到训练的影响。
