IgG-抗 IgA 抗体：寻常型银屑病患者的自身免疫性发现。
IgG-anti-IgA antibodies: an autoimmune finding in patients with psoriasis vulgaris.
机构信息
Department of Pediatric Immunology, Ege University Medical School, Izmir, Turkey.
出版信息
Minerva Med. 2012 Jun;103(3):183-7.
AIM
Psoriasis is thought to be an autoimmune disease caused by inappropriate activation of the cellular immune system. In this study, we aimed to search out IgG-anti-IgA antibody levels, serum immunoglobulins and antinuclear antibodies (ANA).
METHODS
The study enrolled 38 psoriasis vulgaris patients and 40 healthy controls.
RESULTS
Mean IgG-anti-IgA levels were significantly higher in psoriasis patients. The frequency of positive ANA testing was 21.1%; however, there was no correlation between IgG-anti-IgA antibody levels and ANA positivity. Only one patient had low IgA levels without high IgG-anti-IgA concentrations.
CONCLUSION
The data about high IgG-anti-IgA antibody levels are noteworthy for a new evidence of autoimmune mechanism.
目的
银屑病被认为是一种由细胞免疫系统异常激活引起的自身免疫性疾病。本研究旨在检测 IgG-抗 IgA 抗体水平、血清免疫球蛋白和抗核抗体（ANA）。
方法
本研究纳入 38 例寻常型银屑病患者和 40 例健康对照者。
结果
银屑病患者 IgG-抗 IgA 水平显著升高。ANA 阳性率为 21.1%；然而，IgG-抗 IgA 抗体水平与 ANA 阳性之间无相关性。仅有 1 例患者出现低 IgA 血症而 IgG-抗 IgA 浓度不高。
结论
关于 IgG-抗 IgA 抗体水平升高的数据为自身免疫机制的新证据提供了重要依据。
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