[寻常型银屑病患者血清中抗真菌抗原的IgG、IgA和IgM抗体水平]
[Serum levels of antibodies for IgG, IgA, and IgM against the fungi antigen in psoriasis vulgaris].
作者信息
Liang Yun-sheng, Wen Hai-quan, Xiao Rong
机构信息
Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
出版信息
Hunan Yi Ke Da Xue Xue Bao. 2003 Dec;28(6):638-40.
OBJECTIVE
To detect the serum levels of antibodies against Malassezia further and Candida albicans in patients with psoriasis vulgaris (PV), and to investigate the relationship between Malassezia furfur or Candida albicans and pathogenesis of PV.
METHODS
The serum levels of antibodies for IgG, IgA, and IgM against the whole cell antigen Wag and soluble antigen (Sag) of Malassezia fufur and Candida albicans in 40 PV patients and 20 healthy controls were detected by indirect-ELISA, RESULTS: The serum levels of IgG against Wag of Malassezia furfur and Candida albicans were significantly higher in PV patients than those in the healthy controls (P < 0.01, P < 0.05, respectively), The serum levels of IgM against Sag of Malassezia furfur and Candida albican, IgA against Sag of Candida albicans were significantly lower in PV patients than those in the healthy controls (P < 0.05).
CONCLUSION
There are some humoral immunity abnormalties in PV patients. Malassezia furfur and Candida albicans may be related to the pathogenesis of PV.
目的
进一步检测寻常型银屑病（PV）患者血清中抗马拉色菌和白色念珠菌抗体水平，探讨糠秕马拉色菌或白色念珠菌与PV发病机制之间的关系。
方法
采用间接酶联免疫吸附测定法（间接-ELISA）检测40例PV患者及20例健康对照血清中针对糠秕马拉色菌和白色念珠菌全细胞抗原Wag及可溶性抗原（Sag）的IgG、IgA和IgM抗体水平。
结果
PV患者血清中抗糠秕马拉色菌和白色念珠菌Wag的IgG水平显著高于健康对照（分别为P < 0.01，P < 0.05）；PV患者血清中抗糠秕马拉色菌和白色念珠菌Sag的IgM水平、抗白色念珠菌Sag的IgA水平显著低于健康对照（P < 0.05）。
结论
PV患者存在一些体液免疫异常。糠秕马拉色菌和白色念珠菌可能与PV的发病机制有关。
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