Department of Nutrigenomics and Bromatology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Sosnowiec, Poland.
Department of Molecular Biology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Sosnowiec, Poland.
Med Sci Monit. 2020 Jun 22;26:e922035. doi: 10.12659/MSM.922035.
Apoptosis is a natural physiological process involving programmed cell death. Thanks to this process, it is possible to maintain the homeostasis of the body and the immune system. Dysfunctions of this mechanism lead to development of autoimmune diseases such as psoriasis; these diseases are chronic and treatment is extremely difficult. In psoriasis (a skin disease), apoptosis disorders are manifested by keratinocyte proliferation dysfunction. Autoimmune diseases coexisting with psoriasis include multiple sclerosis, autoimmune thyroid disease, and diabetes, but the common pathogenesis of these diseases is not fully understood. Given the heterogenous nature and chronic and recurrent course of psoriasis, the selection of an effective therapeutic strategy is still a problem. This literature review was focused on the process of apoptosis as a factor in the development of autoimmune diseases, with particular emphasis on psoriasis. The work also includes a review of therapeutic methods of psoriasis based on the latest literature.
细胞凋亡是一种涉及程序性细胞死亡的自然生理过程。由于这个过程，才有可能维持身体和免疫系统的内稳态。该机制的功能障碍会导致自身免疫性疾病的发展，如牛皮癣；这些疾病是慢性的，治疗极其困难。在牛皮癣（一种皮肤病）中，细胞凋亡紊乱表现为角质形成细胞增殖功能障碍。与牛皮癣共存的自身免疫性疾病包括多发性硬化症、自身免疫性甲状腺疾病和糖尿病，但这些疾病的共同发病机制尚未完全了解。鉴于牛皮癣的异质性、慢性和复发性，选择有效的治疗策略仍然是一个问题。本文献综述重点介绍了细胞凋亡作为自身免疫性疾病发展的一个因素，特别强调了牛皮癣。该工作还包括根据最新文献综述牛皮癣的治疗方法。
